Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.

Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.

OBJECTIVE: Reporter transgenes were introduced into the type 1 tight-skin (Tsk1/+) mouse model of scleroderma to test the hypothesis that fibroblast-specific genetic programs are activated in fibrosis. METHODS: Transgenes harboring upstream fragments of the 5' flanking region of the mouse proal...

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Detalhes bibliográficos
Principais autores:	Denton, C, Zheng, B, Shiwen, X, Zhang, Z, Bou-Gharios, G, Eberspaecher, H, Black, C, de Crombrugghe, B
Formato:	Journal article
Idioma:	English
Publicado em:	2001

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