Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG

Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG

H3K27M mutations resulting in epigenetic dysfunction are frequently observed in diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a CRISPR screen revealing that knockout of KDM1A encoding lysine-specific demethylase 1 (LSD1) sensitizes DIPG cells to histone deacetyl...

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Hauptverfasser: Anastas, JN, Zee, BM, Kalin, JH, Kim, M, Guo, R, Alexandrescu, S, Blanco, MA, Giera, S, Gillespie, SM, Das, J, Wu, M, Nocco, S, Bonal, DM, Nguyen, Q-D, Suva, ML, Bernstein, BE, Alani, R, Golub, TR, Cole, PA, Filbin, MG, Shi, Y
Format: Journal article
Sprache:English
Veröffentlicht: Cell Press 2019

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