DNA polymerase conformational dynamics and the role of fidelity-conferring residues: Insights from computational simulations

DNA polymerase conformational dynamics and the role of fidelity-conferring residues: Insights from computational simulations

Herein we investigate the molecular bases of DNA polymerase I conformational dynamics that underlie the replication fidelity of the enzyme. Such fidelity is determined by conformational changes that promote the rejection of incorrect nucleotides before the chemical ligation step. We report a compreh...

书目详细资料
Main Authors:	Meli, M, Sustarsic, M, Craggs, T, Kapanidis, A, Colombo, G
格式:	Journal article
语言:	English
出版:	Frontiers Media 2016

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