An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

The common view is that T lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily naïve and central memory cells) elongated telomeres by acquiring telomere vesicles from antigen-presenting cells (APCs) independently of telomerase action. Upon contact with these...

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Bibliographic Details
Main Authors: Lanna, A, Vaz, B, D’Ambra, C, Valvo, S, Vuotto, C, Chiurchiù, V, Devine, O, Sanchez, M, Borsellino, G, Akbar, AN, De Bardi, M, Gilroy, DW, Dustin, ML, Blumer, B, Karin, M
Format: Journal article
Language:English
Published: Springer Nature 2022

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