Higher fish consumption and lower risk of central nervous system demyelination
Background/Objectives: The evidence for diet as a risk factor for multiple sclerosis (MS) is inconclusive. We examined the associations between fish consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Methods: The 2003–2006 Ausi...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2019
|
| _version_ | 1797064534182068224 |
|---|---|
| author | Black, L Zhao, Y Peng, Y Sherriff, J Lucas, R Van Der Mei, I Pereira, G Ausimmune Investigator Group |
| author2 | Chapman, C |
| author_facet | Chapman, C Black, L Zhao, Y Peng, Y Sherriff, J Lucas, R Van Der Mei, I Pereira, G Ausimmune Investigator Group |
| author_sort | Black, L |
| collection | OXFORD |
| description | Background/Objectives: The evidence for diet as a risk factor for multiple sclerosis (MS) is inconclusive. We examined the associations between fish consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Methods: The 2003–2006 Ausimmune Study was a case-control study examining environmental risk factors for FCD, with participants recruited from four regions of Australia and matched on age, sex, and study region. Dietary intake data were collected using a food frequency questionnaire. We used conditional logistic regression models to test associations between fish consumption (total, tinned, grilled, and fried) and risk of FCD (249 cases and 438 controls), adjusting for history of infectious mononucleosis, smoking, serum 25-hydroxyvitamin D concentrations, socio-economic status, omega-3 supplement use, dietary under-reporting, and total energy intake. Results: Higher total fish consumption (per 30 g/day, equivalent to two serves/week) was associated with an 18% reduced risk of FCD (AOR 0.82; 95% CI 0.70, 0.97). While we found no statistically significant associations between grilled and fried fish consumption and risk of FCD, higher tinned fish consumption (per 30 g/day) was associated with a 41% reduced risk of FCD (AOR 0.59; 95% CI 0.39, 0.89). Conclusions: Tinned fish is predominantly oily, whereas grilled and fried fish are likely to be a combination of oily and white types. Oily fish is high in vitamin D and very long chain polyunsaturated omega-3 fatty acids, both of which may be beneficial in relation to MS. |
| first_indexed | 2024-03-06T21:15:43Z |
| format | Journal article |
| id | oxford-uuid:3fba23ef-a49c-4bf1-80bb-5c4759cdae51 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:15:43Z |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:3fba23ef-a49c-4bf1-80bb-5c4759cdae512022-03-26T14:33:44ZHigher fish consumption and lower risk of central nervous system demyelinationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3fba23ef-a49c-4bf1-80bb-5c4759cdae51EnglishSymplectic Elements at OxfordSpringer Nature2019Black, LZhao, YPeng, YSherriff, JLucas, RVan Der Mei, IPereira, GAusimmune Investigator GroupChapman, CCoulthard, ADear, KDwyer, TKilpatrick, TLucas, RMcMichael, TPender, MPonsonby, ATaylor, BValery, PVan Der Mei, IWilliams, DBackground/Objectives: The evidence for diet as a risk factor for multiple sclerosis (MS) is inconclusive. We examined the associations between fish consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Methods: The 2003–2006 Ausimmune Study was a case-control study examining environmental risk factors for FCD, with participants recruited from four regions of Australia and matched on age, sex, and study region. Dietary intake data were collected using a food frequency questionnaire. We used conditional logistic regression models to test associations between fish consumption (total, tinned, grilled, and fried) and risk of FCD (249 cases and 438 controls), adjusting for history of infectious mononucleosis, smoking, serum 25-hydroxyvitamin D concentrations, socio-economic status, omega-3 supplement use, dietary under-reporting, and total energy intake. Results: Higher total fish consumption (per 30 g/day, equivalent to two serves/week) was associated with an 18% reduced risk of FCD (AOR 0.82; 95% CI 0.70, 0.97). While we found no statistically significant associations between grilled and fried fish consumption and risk of FCD, higher tinned fish consumption (per 30 g/day) was associated with a 41% reduced risk of FCD (AOR 0.59; 95% CI 0.39, 0.89). Conclusions: Tinned fish is predominantly oily, whereas grilled and fried fish are likely to be a combination of oily and white types. Oily fish is high in vitamin D and very long chain polyunsaturated omega-3 fatty acids, both of which may be beneficial in relation to MS. |
| spellingShingle | Black, L Zhao, Y Peng, Y Sherriff, J Lucas, R Van Der Mei, I Pereira, G Ausimmune Investigator Group Higher fish consumption and lower risk of central nervous system demyelination |
| title | Higher fish consumption and lower risk of central nervous system demyelination |
| title_full | Higher fish consumption and lower risk of central nervous system demyelination |
| title_fullStr | Higher fish consumption and lower risk of central nervous system demyelination |
| title_full_unstemmed | Higher fish consumption and lower risk of central nervous system demyelination |
| title_short | Higher fish consumption and lower risk of central nervous system demyelination |
| title_sort | higher fish consumption and lower risk of central nervous system demyelination |
| work_keys_str_mv | AT blackl higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT zhaoy higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT pengy higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT sherriffj higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT lucasr higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT vandermeii higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT pereirag higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination AT ausimmuneinvestigatorgroup higherfishconsumptionandlowerriskofcentralnervoussystemdemyelination |