Investigating mechanisms of TDP-43 toxicity in cellular models of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disorder for which there is currently no cure. TDP-43 cytoplasmic mislocalisation and aggregation are the pathological hallmarks of the disease, and mutations in the gene encoding TDP-43, TARDBP, have been observed in a small number o...
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| Format: | Thesis |
| Language: | English |
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2022
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