GTP cyclohydrolase II structure and mechanism.

GTP cyclohydrolase II structure and mechanism.

GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The essential role of riboflavin in metabolism and the absence of GTP cyclohydrolase II in higher eukaryotes makes it a potenti...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Ren, J, Kotaka, M, Lockyer, M, Lamb, H, Hawkins, A, Stammers, D
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2005

Antzeko izenburuak

Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts
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GTP cyclohydrolase as a novel mechanism for tumour growth
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GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
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Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
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The protein partners of GTP cyclohydrolase I in rat organs.
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Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine.
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GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
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GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
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Control of GTP Cyclohydrolase I Activity during Aggregation of Dictyostelium discoideum
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Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene
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Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
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GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
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Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
nork: Anderson Michelle A, et al.
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Endothelial-specific GTP cyclohydrolase overexpression reduces blood pressure in salt-sensitive hypertension
nork: Chen, A, et al.
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Decreased Cardiac Allograft Rejection in Mice Over-Expressing Human GTP Cyclohydrolase I.
nork: Irina, I, et al.
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Brain Transplantation of Neural Stem Cells Cotransduced with Tyrosine Hydroxylase and GTP Cyclohydrolase 1 in Parkinsonian Rats
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Lack of influence of GTP cyclohydrolase gene (<it>GCH1</it>) variations on pain sensitivity in humans
nork: Dionne Raymond A, et al.
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Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
nork: Adlam, D, et al.
Argitaratua: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
nork: Carnicer, R, et al.
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Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
nork: Yanan Liu, et al.
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Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
nork: Adlam, D, et al.
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Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
nork: Chuaiphichai, S, et al.
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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
nork: Carnicer, R, et al.
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Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.
nork: Starr, A, et al.
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Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation.
nork: Yu Zhao, et al.
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Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension
nork: Du, Y, et al.
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Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension\
nork: Du, Y, et al.
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303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
nork: Chuaiphichai, S, et al.
Argitaratua: (2014)

Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
nork: Wang, W, et al.
Argitaratua: (2008)

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain
nork: Sakamoto Hideo, et al.
Argitaratua: (1997-09-01)

Genomic Organization of Mouse and Human GTP Cyclohydrolase I Genes and Mutations Found in the Human Gene
nork: Ichinose Hiroshi, et al.
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Cardiomyocyte-Targeted Overexpression of GTP Cyclohydrolase-1 Increases Myocyte Lusitropy and Reduces Superoxide Production
nork: Carnicer, R, et al.
Argitaratua: (2010)

Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
nork: Liao, S, et al.
Argitaratua: (2007)

Endothelial-specific GTP cyclohydrolase I overexpression prevents blood pressure progression in salt-sensitive hypertension
nork: Chen, A, et al.
Argitaratua: (2005)

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
nork: Hussein, D, et al.
Argitaratua: (2015)

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation
nork: Carnicer, R, et al.
Argitaratua: (2011)

GTP cyclohydrolase I and tyrosine hydroxylase gene mutations in familial and sporadic dopa-responsive dystonia patients.
nork: Chunyou Cai, et al.
Argitaratua: (2013-01-01)

Co-ordinate Expression of GTP Cyclohydrolase I and Inducible Nitric Oxide Synthase in Rat Mesangial Cells
nork: Plüss Christoph, et al.
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