Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active site binding of electrophile bearing compounds enables susbsequent covalent reaction with a lysine residue (K408...
Full description
Bibliographic Details
| Main Authors: |
Bush, J,
Lesniak, R,
Yeh, T,
Belle, R,
Kramer, H,
Tumber, A,
Chowdhury, R,
Flashman, E,
Mecinovic, J,
Schofield, C |
|---|
| Format: | Journal article
|
|---|
| Published: |
Royal Society of Chemistry
2018
|
|---|