A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis.
The complexity of multiple sclerosis (MS) genetics has made the search for novel genes using traditional sharing methods problematic. In order to minimize the genetic heterogeneity present in the MS population we have screened the Canadian MS population for individuals belonging to the Hutterite Bre...
| 主要な著者: | , , , , , , , , , , , , , |
|---|---|
| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2008
|
| _version_ | 1826268861243064320 |
|---|---|
| author | Dyment, D Cader, M Datta, A Broxholme, S Cherny, S Willer, C Ramagopalan, S Herrera, B Orton, S Chao, M Sadovnick, A Hader, M Hader, W Ebers, G |
| author_facet | Dyment, D Cader, M Datta, A Broxholme, S Cherny, S Willer, C Ramagopalan, S Herrera, B Orton, S Chao, M Sadovnick, A Hader, M Hader, W Ebers, G |
| author_sort | Dyment, D |
| collection | OXFORD |
| description | The complexity of multiple sclerosis (MS) genetics has made the search for novel genes using traditional sharing methods problematic. In order to minimize the genetic heterogeneity present in the MS population we have screened the Canadian MS population for individuals belonging to the Hutterite Brethren. Seven Hutterites with clinically definite MS were ascertained and are related to a common founder by eight generations. Six of the 7 affected individuals and 21 of their unaffected family members (total = 27) were genotyped for 807 markers. Haplotypes were then inspected for sharing among the six MS patients. There were three haplotypes shared among all six MS patients. The haplotypes were located at 2q34-35, 4q31-32, and 17p13. An additional 15 haplotypes were shared among five of the six Hutterites MS patients. The HLA Class II region was one of the highlighted regions; however, the shared MHC haplotype bore the DRB1*04 allele and not the MS-associated DRB1*15 allele providing further evidence of the complexity of the MHC. Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population. |
| first_indexed | 2024-03-06T21:16:05Z |
| format | Journal article |
| id | oxford-uuid:3fd4dc26-42b5-49e5-bf66-9a86b3849249 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:16:05Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:3fd4dc26-42b5-49e5-bf66-9a86b38492492022-03-26T14:34:28ZA first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3fd4dc26-42b5-49e5-bf66-9a86b3849249EnglishSymplectic Elements at Oxford2008Dyment, DCader, MDatta, ABroxholme, SCherny, SWiller, CRamagopalan, SHerrera, BOrton, SChao, MSadovnick, AHader, MHader, WEbers, GThe complexity of multiple sclerosis (MS) genetics has made the search for novel genes using traditional sharing methods problematic. In order to minimize the genetic heterogeneity present in the MS population we have screened the Canadian MS population for individuals belonging to the Hutterite Brethren. Seven Hutterites with clinically definite MS were ascertained and are related to a common founder by eight generations. Six of the 7 affected individuals and 21 of their unaffected family members (total = 27) were genotyped for 807 markers. Haplotypes were then inspected for sharing among the six MS patients. There were three haplotypes shared among all six MS patients. The haplotypes were located at 2q34-35, 4q31-32, and 17p13. An additional 15 haplotypes were shared among five of the six Hutterites MS patients. The HLA Class II region was one of the highlighted regions; however, the shared MHC haplotype bore the DRB1*04 allele and not the MS-associated DRB1*15 allele providing further evidence of the complexity of the MHC. Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population. |
| spellingShingle | Dyment, D Cader, M Datta, A Broxholme, S Cherny, S Willer, C Ramagopalan, S Herrera, B Orton, S Chao, M Sadovnick, A Hader, M Hader, W Ebers, G A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title | A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title_full | A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title_fullStr | A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title_full_unstemmed | A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title_short | A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis. |
| title_sort | first stage genome wide screen for regions shared identical by descent in hutterite families with multiple sclerosis |
| work_keys_str_mv | AT dymentd afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT caderm afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT dattaa afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT broxholmes afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT chernys afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT willerc afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ramagopalans afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT herrerab afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ortons afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT chaom afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT sadovnicka afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT haderm afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT haderw afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ebersg afirststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT dymentd firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT caderm firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT dattaa firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT broxholmes firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT chernys firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT willerc firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ramagopalans firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT herrerab firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ortons firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT chaom firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT sadovnicka firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT haderm firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT haderw firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis AT ebersg firststagegenomewidescreenforregionssharedidenticalbydescentinhutteritefamilieswithmultiplesclerosis |