Neuroticism as a predictor of mood change: the effects of tryptophan depletion.
BACKGROUND: Acute tryptophan depletion (ATD) results in a transient lowering of mood in patients recovered from depression and in healthy volunteers with a family history of affective disorders. The personality trait of neuroticism is strongly associated with depression. AIMS: To assess whether neu...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1797064563973160960 |
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| author | Stewart, M Deary, I Ebmeier, K |
| author_facet | Stewart, M Deary, I Ebmeier, K |
| author_sort | Stewart, M |
| collection | OXFORD |
| description | BACKGROUND: Acute tryptophan depletion (ATD) results in a transient lowering of mood in patients recovered from depression and in healthy volunteers with a family history of affective disorders. The personality trait of neuroticism is strongly associated with depression. AIMS: To assess whether neuroticism predicts mood change in response to ATD in healthy volunteers. METHOD: Healthy volunteers who scored at the top and bottom fifth percentiles of neuroticism scores (17 and 15 respectively) were selected. In a double-blind, crossover study they received a tryptophan-free or a control drink. Mood and cognition were assessed. RESULTS: Neuroticism did not predict the amount of mood change following ATD but did moderate performance on the verbal fluency test. A family history of affective disorder (n=5) predicted mood change but not cognitive function following ATD. CONCLUSIONS: Neuroticism moderates aspects of cognitive function, but in this study it was not strongly related with mood change via serotonin. |
| first_indexed | 2024-03-06T21:16:10Z |
| format | Journal article |
| id | oxford-uuid:3fda3e60-4ce3-4cff-a377-6c135fdabd2b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:16:10Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:3fda3e60-4ce3-4cff-a377-6c135fdabd2b2022-03-26T14:34:35ZNeuroticism as a predictor of mood change: the effects of tryptophan depletion.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3fda3e60-4ce3-4cff-a377-6c135fdabd2bEnglishSymplectic Elements at Oxford2002Stewart, MDeary, IEbmeier, K BACKGROUND: Acute tryptophan depletion (ATD) results in a transient lowering of mood in patients recovered from depression and in healthy volunteers with a family history of affective disorders. The personality trait of neuroticism is strongly associated with depression. AIMS: To assess whether neuroticism predicts mood change in response to ATD in healthy volunteers. METHOD: Healthy volunteers who scored at the top and bottom fifth percentiles of neuroticism scores (17 and 15 respectively) were selected. In a double-blind, crossover study they received a tryptophan-free or a control drink. Mood and cognition were assessed. RESULTS: Neuroticism did not predict the amount of mood change following ATD but did moderate performance on the verbal fluency test. A family history of affective disorder (n=5) predicted mood change but not cognitive function following ATD. CONCLUSIONS: Neuroticism moderates aspects of cognitive function, but in this study it was not strongly related with mood change via serotonin. |
| spellingShingle | Stewart, M Deary, I Ebmeier, K Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title | Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title_full | Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title_fullStr | Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title_full_unstemmed | Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title_short | Neuroticism as a predictor of mood change: the effects of tryptophan depletion. |
| title_sort | neuroticism as a predictor of mood change the effects of tryptophan depletion |
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