Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
OBJECTIVE: Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming gro...
Główni autorzy: | Shi-wen, X, Kennedy, L, Renzoni, E, Bou-Gharios, G, du Bois, R, Black, C, Denton, C, Abraham, D, Leask, A |
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Format: | Journal article |
Język: | English |
Wydane: |
2007
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