Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB)
2-Aminobenzamide (2AB) is a common fluorescence label attached to reducing oligosaccharides by a reductive amination procedure. Chemical investigation of the published literature procedure reveals labelling occurs by the expected mechanism for both protected and unprotected glucose derivatives to yi...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1797064595894960128 |
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| author | France, R Cumpstey, I Butters, T Fairbanks, A Wormald, M |
| author_facet | France, R Cumpstey, I Butters, T Fairbanks, A Wormald, M |
| author_sort | France, R |
| collection | OXFORD |
| description | 2-Aminobenzamide (2AB) is a common fluorescence label attached to reducing oligosaccharides by a reductive amination procedure. Chemical investigation of the published literature procedure reveals labelling occurs by the expected mechanism for both protected and unprotected glucose derivatives to yield open-chain carbohydrates rather than result in the formation of any heterocyclic materials. Pentenyl glucosides may also be readily attached to the 2AB label by a sequence of dihydroxylation, periodate cleavage and subsequent reductive amination of the resulting aldehyde. 2AB labelling is compatible with deprotection of both acetate and benzyl protecting groups. © 2001 Elsevier Science Ltd. |
| first_indexed | 2024-03-06T21:16:38Z |
| format | Journal article |
| id | oxford-uuid:40002bf9-0e6e-48e6-aeda-39240ecef6d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:16:38Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:40002bf9-0e6e-48e6-aeda-39240ecef6d62022-03-26T14:35:21ZFluorescence labelling of carbohydrates with 2-aminobenzamide (2AB)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:40002bf9-0e6e-48e6-aeda-39240ecef6d6EnglishSymplectic Elements at Oxford2000France, RCumpstey, IButters, TFairbanks, AWormald, M2-Aminobenzamide (2AB) is a common fluorescence label attached to reducing oligosaccharides by a reductive amination procedure. Chemical investigation of the published literature procedure reveals labelling occurs by the expected mechanism for both protected and unprotected glucose derivatives to yield open-chain carbohydrates rather than result in the formation of any heterocyclic materials. Pentenyl glucosides may also be readily attached to the 2AB label by a sequence of dihydroxylation, periodate cleavage and subsequent reductive amination of the resulting aldehyde. 2AB labelling is compatible with deprotection of both acetate and benzyl protecting groups. © 2001 Elsevier Science Ltd. |
| spellingShingle | France, R Cumpstey, I Butters, T Fairbanks, A Wormald, M Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title | Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title_full | Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title_fullStr | Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title_full_unstemmed | Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title_short | Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB) |
| title_sort | fluorescence labelling of carbohydrates with 2 aminobenzamide 2ab |
| work_keys_str_mv | AT francer fluorescencelabellingofcarbohydrateswith2aminobenzamide2ab AT cumpsteyi fluorescencelabellingofcarbohydrateswith2aminobenzamide2ab AT butterst fluorescencelabellingofcarbohydrateswith2aminobenzamide2ab AT fairbanksa fluorescencelabellingofcarbohydrateswith2aminobenzamide2ab AT wormaldm fluorescencelabellingofcarbohydrateswith2aminobenzamide2ab |