Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine

Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Faller, K, Atzler, D, McAndrew, D, Zervou, S, Whittington, H, Simon, J, Aksentijevic, D, Hove, M, Choe, C, Isbrandt, D, Casadei, B, Schneider, J, Neubauer, S, Lygate, C
פורמט:	Journal article
שפה:	English
יצא לאור:	Oxford University Press 2017

פריטים דומים

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
מאת: Lygate, CA, et al.
יצא לאור: (2022)

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
מאת: Craig A. Lygate, et al.
יצא לאור: (2022-08-01)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
מאת: McAndrew, DJ, et al.
יצא לאור: (2022)

Complete absence of creatine but unaltered ATP levels in hearts from AGAT knockout mice
מאת: ten Hove, M, et al.
יצא לאור: (2007)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
מאת: Debra J. McAndrew, et al.
יצא לאור: (2023-02-01)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
מאת: Lygate, C, et al.
יצא לאור: (2013)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
מאת: Aksentijević, D, et al.
יצא לאור: (2014)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
מאת: Zervou, S, et al.
יצא לאור: (2010)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
מאת: Lygate, C, et al.
יצא לאור: (2012)

Creatine uptake in mouse hearts with genetically altered creatine levels.
מאת: ten Hove, M, et al.
יצא לאור: (2008)

Cardiomyocytes from Creatine-Deficient Mice Lacking L-Arginine: Glycine Amidinotransferase (AGAT) Show No Changes in Mitochondrial Organization and Cellular Compartmentation
מאת: Kotlyarova, S, et al.
יצא לאור: (2013)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.
מאת: Dunja Aksentijević, et al.
יצא לאור: (2014-01-01)

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
מאת: Lygate, C, et al.
יצא לאור: (2011)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
מאת: Lygate, C, et al.
יצא לאור: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
מאת: Lygate, C, et al.
יצא לאור: (2013)

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure
מאת: Atzler, D, et al.
יצא לאור: (2017)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
מאת: Makinen, K, et al.
יצא לאור: (2008)

Protective effect of creatine elevation against ischaemia reperfusion injury is retained in the presence of co-morbidities and during cardioplegia.
מאת: Whittington, H, et al.
יצא לאור: (2016)

Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging
מאת: Lygate, C, et al.
יצא לאור: (2011)

Evidence of an intracellular creatine-sensing mechanism that modulates creatine biosynthesis via AGAT expression in human HAP1 cells
מאת: Michael B. Tropak, et al.
יצא לאור: (2023-12-01)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
מאת: Lygate, C, et al.
יצא לאור: (2006)

Augmentation of creatine kinase in vitro protects against simulated ischaemia reperfusion injury
מאת: Zervou, S, et al.
יצא לאור: (2017)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
מאת: Cao, F, et al.
יצא לאור: (2020)

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
מאת: Faller, K, et al.
יצא לאור: (2013)

1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism
מאת: Faller, K, et al.
יצא לאור: (2013)

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism.
מאת: Faller, K, et al.
יצא לאור: (2013)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
מאת: Lygate, C, et al.
יצא לאור: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
מאת: Lygate, C, et al.
יצא לאור: (2012)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
מאת: Ten Hove, M, et al.
יצא לאור: (2007)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion
מאת: Whittington, H, et al.
יצא לאור: (2018)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro
מאת: Zervou, S, et al.
יצא לאור: (2017)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
מאת: Zervou, S, et al.
יצא לאור: (2013)

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury
מאת: Cao, F, et al.
יצא לאור: (2018)

Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart
מאת: Branovets, J, et al.
יצא לאור: (2013)

Dissociation of AGAT, GAMT and SLC6A8 in CNS: Relevance to creatine deficiency syndromes
מאת: Olivier Braissant, et al.
יצא לאור: (2010-02-01)

Screening for small molecule regulators of the creatine transporter (SLC6A8)
מאת: Zervou, S, et al.
יצא לאור: (2020)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
מאת: Zervou, S, et al.
יצא לאור: (2013)

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.
מאת: Zervou, S, et al.
יצא לאור: (2016)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
מאת: Maguire, ML, et al.
יצא לאור: (2023)

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.
מאת: Hannah J Whittington, et al.
יצא לאור: (2016-01-01)