Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.
Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotyp...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826268908478267392 |
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| author | Thananchai, H Gillespie, G Martin, M Bashirova, A Yawata, N Yawata, M Easterbrook, P McVicar, D Maenaka, K Parham, P Carrington, M Dong, T Rowland-Jones, S |
| author_facet | Thananchai, H Gillespie, G Martin, M Bashirova, A Yawata, N Yawata, M Easterbrook, P McVicar, D Maenaka, K Parham, P Carrington, M Dong, T Rowland-Jones, S |
| author_sort | Thananchai, H |
| collection | OXFORD |
| description | Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with different binding specificities. Only KIR3DL1*005 bound both HLA-A*2402 and HLA-B*5703 tetramers. HLA-A*2402-expressing target cells were resistant to lysis by NK cells expressing KIR3DL1*001 or *005. This study shows that HLA-A*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4(+) ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism. |
| first_indexed | 2024-03-06T21:16:46Z |
| format | Journal article |
| id | oxford-uuid:400b2f5a-4976-404e-b52b-668207bc7db1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:16:46Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:400b2f5a-4976-404e-b52b-668207bc7db12022-03-26T14:35:39ZCutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:400b2f5a-4976-404e-b52b-668207bc7db1EnglishSymplectic Elements at Oxford2007Thananchai, HGillespie, GMartin, MBashirova, AYawata, NYawata, MEasterbrook, PMcVicar, DMaenaka, KParham, PCarrington, MDong, TRowland-Jones, SAlthough it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with different binding specificities. Only KIR3DL1*005 bound both HLA-A*2402 and HLA-B*5703 tetramers. HLA-A*2402-expressing target cells were resistant to lysis by NK cells expressing KIR3DL1*001 or *005. This study shows that HLA-A*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4(+) ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism. |
| spellingShingle | Thananchai, H Gillespie, G Martin, M Bashirova, A Yawata, N Yawata, M Easterbrook, P McVicar, D Maenaka, K Parham, P Carrington, M Dong, T Rowland-Jones, S Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title | Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title_full | Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title_fullStr | Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title_full_unstemmed | Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title_short | Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. |
| title_sort | cutting edge allele specific and peptide dependent interactions between kir3dl1 and hla a and hla b |
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