Photoaffinity labelling of isopenicillin N synthetase.

The alpha-aminoadipoyl group of the natural substrate of isopenicillin N synthetase (IPNS), L-alpha-aminoadipoyl-L-cysteinyl-D-valine (ACV), has been replaced by a diazirinyl-containing group, which can be photoactivated. This has allowed investigation of the substrate binding site of IPNS by photoa...

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Bibliografiske detaljer
Main Authors: Baldwin, J, Coates, J, Moloney, M, Pratt, A, Willis, A
Format: Journal article
Sprog:English
Udgivet: 1990