Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA)
<strong>Aims<br></strong> We investigated the antibacterial efficacy of Umonium<sup>38</sup> and Virkon<sup>®</sup> against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) up to 14 da...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2024
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| _version_ | 1797113120506773504 |
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| author | Ruanchaiman, S Amornchai, P Wuthiekanun, V Langla, S Maroongruang, P Le, KK Blacksell, SD |
| author_facet | Ruanchaiman, S Amornchai, P Wuthiekanun, V Langla, S Maroongruang, P Le, KK Blacksell, SD |
| author_sort | Ruanchaiman, S |
| collection | OXFORD |
| description | <strong>Aims<br></strong>
We investigated the antibacterial efficacy of Umonium<sup>38</sup> and Virkon<sup>®</sup> against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) up to 14 days following treatment.
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Methods and results<br></strong>
Umonium<sup>38</sup> was diluted to 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3%, tested against the bacterial strains at various contact times (15 min to 24 h), and incubated for up to 14 days. A minimum concentration of 0.5% Umonium<sup>38</sup> with a contact time of 15 min effectively killed approximately 10<sup>8</sup> CFU/ml of all four bacterial species. No growth was observed on agar plates from day 0 until day 14 for all six concentrations. The bacteria were also inactivated by a 30-minute treatment time using Virkon<sup>®</sup> 1% solution.
<br><strong>
Conclusions<br></strong>
Umonium<sup>38</sup> effectively inactivates B. pseudomallei, E. coli, P. aeruginosa and MRSA at a concentration of ≥ 0.5% with a contact time of at least 15 min. The antimicrobial effect of Umonium<sup>38</sup> remained for 14 days. |
| first_indexed | 2024-04-09T03:57:38Z |
| format | Journal article |
| id | oxford-uuid:401cdf95-d2cf-4d50-b3aa-dab0a05daad0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:57:38Z |
| publishDate | 2024 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:401cdf95-d2cf-4d50-b3aa-dab0a05daad02024-04-03T13:59:42ZEffectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:401cdf95-d2cf-4d50-b3aa-dab0a05daad0EnglishSymplectic ElementsBioMed Central2024Ruanchaiman, SAmornchai, PWuthiekanun, VLangla, SMaroongruang, PLe, KKBlacksell, SD<strong>Aims<br></strong> We investigated the antibacterial efficacy of Umonium<sup>38</sup> and Virkon<sup>®</sup> against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) up to 14 days following treatment. <br><strong> Methods and results<br></strong> Umonium<sup>38</sup> was diluted to 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3%, tested against the bacterial strains at various contact times (15 min to 24 h), and incubated for up to 14 days. A minimum concentration of 0.5% Umonium<sup>38</sup> with a contact time of 15 min effectively killed approximately 10<sup>8</sup> CFU/ml of all four bacterial species. No growth was observed on agar plates from day 0 until day 14 for all six concentrations. The bacteria were also inactivated by a 30-minute treatment time using Virkon<sup>®</sup> 1% solution. <br><strong> Conclusions<br></strong> Umonium<sup>38</sup> effectively inactivates B. pseudomallei, E. coli, P. aeruginosa and MRSA at a concentration of ≥ 0.5% with a contact time of at least 15 min. The antimicrobial effect of Umonium<sup>38</sup> remained for 14 days. |
| spellingShingle | Ruanchaiman, S Amornchai, P Wuthiekanun, V Langla, S Maroongruang, P Le, KK Blacksell, SD Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title | Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_full | Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_fullStr | Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_full_unstemmed | Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_short | Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_sort | effectiveness of umonium38 against burkholderia pseudomallei escherichia coli pseudomonas aeruginosa and methicillin resistant staphylococcus aureus mrsa |
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