The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis
PURPOSE OF REVIEW: Natural killer (NK) cells, gamma delta (γδ) T-cells and other innate immune cells are important lymphocyte subsets able both to produce cytokines including the pro-inflammatory cytokine IL-17 and to kill cellular targets. This review describes the features of NK cells, γδ T-cells...
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Journal article |
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2013
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| _version_ | 1826268950533505024 |
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| author | Al-Mossawi, M Ridley, A Kiedel, S Bowness, P |
| author_facet | Al-Mossawi, M Ridley, A Kiedel, S Bowness, P |
| author_sort | Al-Mossawi, M |
| collection | OXFORD |
| description | PURPOSE OF REVIEW: Natural killer (NK) cells, gamma delta (γδ) T-cells and other innate immune cells are important lymphocyte subsets able both to produce cytokines including the pro-inflammatory cytokine IL-17 and to kill cellular targets. This review describes the features of NK cells, γδ T-cells and other innate immune cells, and outlines the evidence for their potential pathogenic roles in spondyloarthritis (SpA). RECENT FINDINGS: NK cells and T cells both express receptors that recognize aberrantly folded human leucocyte antigen. This interaction seems to polarize towards a type 17 immunity programme which has been increasingly implicated in SpA pathology. γδ T-cells have also been shown to be polarized towards a type 17 immunity programme in SpA. Gut interactions with the microbiome can influence NK and innate lymphoid immune responses in SpA and other related diseases. A newly identified population of resident lymphoid cells at the enthesis for the first time offers an explanation for the anatomical localization of SpA. SUMMARY: NK cells, γδ T-cells and other innate immune cells are capable of sharing expression of both transcription factors, including RORγt, and cell surface receptors, such as the killer immunoglobulin-like receptors. There is increasing genetic and functional evidence that they contribute to the RORγt-driven inflammatory type 17 immune responses, and they may link gut inflammation and joint pathology in SpA. © 2013 Wolters Kluwer Health / Lippincott Williams and Wilkins. |
| first_indexed | 2024-03-06T21:17:23Z |
| format | Journal article |
| id | oxford-uuid:403c7878-228f-4b2d-8d53-34d2b94251bd |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:17:23Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:403c7878-228f-4b2d-8d53-34d2b94251bd2022-03-26T14:36:48ZThe role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:403c7878-228f-4b2d-8d53-34d2b94251bdSymplectic Elements at Oxford2013Al-Mossawi, MRidley, AKiedel, SBowness, PPURPOSE OF REVIEW: Natural killer (NK) cells, gamma delta (γδ) T-cells and other innate immune cells are important lymphocyte subsets able both to produce cytokines including the pro-inflammatory cytokine IL-17 and to kill cellular targets. This review describes the features of NK cells, γδ T-cells and other innate immune cells, and outlines the evidence for their potential pathogenic roles in spondyloarthritis (SpA). RECENT FINDINGS: NK cells and T cells both express receptors that recognize aberrantly folded human leucocyte antigen. This interaction seems to polarize towards a type 17 immunity programme which has been increasingly implicated in SpA pathology. γδ T-cells have also been shown to be polarized towards a type 17 immunity programme in SpA. Gut interactions with the microbiome can influence NK and innate lymphoid immune responses in SpA and other related diseases. A newly identified population of resident lymphoid cells at the enthesis for the first time offers an explanation for the anatomical localization of SpA. SUMMARY: NK cells, γδ T-cells and other innate immune cells are capable of sharing expression of both transcription factors, including RORγt, and cell surface receptors, such as the killer immunoglobulin-like receptors. There is increasing genetic and functional evidence that they contribute to the RORγt-driven inflammatory type 17 immune responses, and they may link gut inflammation and joint pathology in SpA. © 2013 Wolters Kluwer Health / Lippincott Williams and Wilkins. |
| spellingShingle | Al-Mossawi, M Ridley, A Kiedel, S Bowness, P The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title | The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title_full | The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title_fullStr | The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title_full_unstemmed | The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title_short | The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis |
| title_sort | role of natural killer cells gamma delta t cells and other innate immune cells in spondyloarthritis |
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