Structure-based design of highly selective inhibitors of the CREB binding protein bromodomain

Structure-based design of highly selective inhibitors of the CREB binding protein bromodomain

Chemical probes are required for preclinical target validation to interrogate novel biological targets and pathways. Selective inhibitors of the CREB binding protein (CREBBP)/EP300 bromodomains are required to facilitate the elucidation of biology associated with these important epigenetic targets....

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Main Authors: Denny, R, Flick, A, Coe, J, Langille, J, Basak, A, Liu, S, Stock, I, Sahasrabudhe, P, Bonin, P, Hay, D, Brennan, P, Pletcher, M, Jones, L, Chekler, E
Format: Journal article
Language:English
Published: American Chemical Society 2017

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