Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells.

The regulation of intracellular pH (pHi) and its role in the insulin-secretory process were evaluated, by using the clonal insulin-secreting cell line RINm5F. Glyceraldehyde, lactate and dihydroxyacetone decreased pHi, but only the first two released insulin. In the presence of extracellular Na+ the...

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Váldodahkkit: Juntti-Berggren, L, Rorsman, P, Siffert, W, Berggren, P
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 1992