Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
The synthesis and inhibitory activity of a series of 5-substituted-(1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-benzo[e][1,2]thiazin-4-ylidene)-thiazolidine-2,4-dione derivatives as competitive inhibitors of recombinant bacterial arylamine-N-acetyltransferases (NATs) are described. The most potent NAT inhi...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797064767991447552 |
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| author | Brooke, E Davies, S Mulvaney, A Okada, M Pompeo, F Sim, E Vickers, R Westwood, I |
| author_facet | Brooke, E Davies, S Mulvaney, A Okada, M Pompeo, F Sim, E Vickers, R Westwood, I |
| author_sort | Brooke, E |
| collection | OXFORD |
| description | The synthesis and inhibitory activity of a series of 5-substituted-(1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-benzo[e][1,2]thiazin-4-ylidene)-thiazolidine-2,4-dione derivatives as competitive inhibitors of recombinant bacterial arylamine-N-acetyltransferases (NATs) are described. The most potent NAT inhibitors are those that contain planar hydrophobic substituents on the sultam nitrogen. |
| first_indexed | 2024-03-06T21:19:04Z |
| format | Journal article |
| id | oxford-uuid:40d1846f-a631-4b81-bc19-841b2e13c19a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:19:04Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:40d1846f-a631-4b81-bc19-841b2e13c19a2022-03-26T14:40:03ZSynthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:40d1846f-a631-4b81-bc19-841b2e13c19aEnglishSymplectic Elements at Oxford2003Brooke, EDavies, SMulvaney, AOkada, MPompeo, FSim, EVickers, RWestwood, IThe synthesis and inhibitory activity of a series of 5-substituted-(1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-benzo[e][1,2]thiazin-4-ylidene)-thiazolidine-2,4-dione derivatives as competitive inhibitors of recombinant bacterial arylamine-N-acetyltransferases (NATs) are described. The most potent NAT inhibitors are those that contain planar hydrophobic substituents on the sultam nitrogen. |
| spellingShingle | Brooke, E Davies, S Mulvaney, A Okada, M Pompeo, F Sim, E Vickers, R Westwood, I Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title | Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title_full | Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title_fullStr | Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title_full_unstemmed | Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title_short | Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). |
| title_sort | synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine n acetyltransferases nats |
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