Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).

The synthesis and inhibitory activity of a series of 5-substituted-(1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-benzo[e][1,2]thiazin-4-ylidene)-thiazolidine-2,4-dione derivatives as competitive inhibitors of recombinant bacterial arylamine-N-acetyltransferases (NATs) are described. The most potent NAT inhi...

Podrobná bibliografie
Hlavní autoři:	Brooke, E, Davies, S, Mulvaney, A, Okada, M, Pompeo, F, Sim, E, Vickers, R, Westwood, I
Médium:	Journal article
Jazyk:	English
Vydáno:	2003

Podobné jednotky

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
Autor: Brooke, E, a další
Vydáno: (2003)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
Autor: Westwood, I, a další
Vydáno: (2011)

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
Autor: Westwood, I, a další
Vydáno: (2010)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Autor: Russell, A, a další
Vydáno: (2009)

Structure and mechanism of arylamine N-acetyltransferases.
Autor: Westwood, I, a další
Vydáno: (2006)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
Autor: Anderton, M, a další
Vydáno: (2006)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
Autor: Laurieri, N, a další
Vydáno: (2014)

Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG
Autor: Eltis, E
Vydáno: (2006)

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
Autor: Sim, E, a další
Vydáno: (2008)

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Autor: Musbah O. M. Tanira, a další
Vydáno: (2003-04-01)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
Autor: Laurieri, N, a další
Vydáno: (2010)

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
Autor: Fullam, E, a další
Vydáno: (2009)

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Autor: Fullam, E, a další
Vydáno: (2013)

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Autor: Fullam, E, a další
Vydáno: (2013)

Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
Autor: Abuhammad, A, a další
Vydáno: (2010)

Arylamine N-acetyltransferase in adult mouse brain
Autor: Mo, M, a další
Vydáno: (2004)

Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.
Autor: Fakis, G, a další
Vydáno: (2000)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
Autor: Wakefield, L, a další
Vydáno: (2008)

Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
Autor: Wakefield, L, a další
Vydáno: (2006)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
Autor: Brooke, E
Vydáno: (2003)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
Autor: Abuhammad, A, a další
Vydáno: (2012)

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.
Autor: Audrey Sabbagh, a další
Vydáno: (2011-01-01)

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.
Autor: Nicola Laurieri, a další
Vydáno: (2014-01-01)

Mapping the genes for arylamine N-acetyltransferases
Autor: Fakis, G
Vydáno: (2000)

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.
Autor: Kawamura, A, a další
Vydáno: (2003)

Arylamine N-acetyltransferase expression during murine heart development
Autor: Wakefield, L, a další
Vydáno: (2004)

Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2
Autor: Samantha M. Carlisle, a další
Vydáno: (2022-01-01)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
Autor: Abuhammad, A, a další
Vydáno: (2010)

Expression of the genes for arylamine N-acetyltransferases in mice
Autor: Boukouvala, S, a další
Vydáno: (2002)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Autor: Areej Abuhammad, a další
Vydáno: (2012-01-01)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
Autor: Madikane, V, a další
Vydáno: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
Autor: Madikane, V, a další
Vydáno: (2007)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
Autor: Wang, H, a další
Vydáno: (2005)

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
Autor: Kawamura, A, a další
Vydáno: (2005)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
Autor: Kawamura, A, a další
Vydáno: (2004)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Autor: Hiba Chelouti, a další
Vydáno: (2017-08-01)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
Autor: Xinning Liu, a další
Vydáno: (2021-01-01)

Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1) and Mouse nat2 (mnat2)
Autor: Laurieri, N, a další
Vydáno: (2010)

Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.
Autor: Adam, P, a další
Vydáno: (2003)

The pharmacogenetics of NAT: structural aspects.
Autor: Pompeo, F, a další
Vydáno: (2002)