Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

beta-Adrenergic signaling via cAMP generation and PKA activation mediates the positive inotropic effect of catecholamines on heart cells. Given the large diversity of protein kinase A targets within cardiac cells, a precisely regulated and confined activity of such signaling pathway is essential for...

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Autors principals:	Mongillo, M, Tocchetti, C, Terrin, A, Lissandron, V, Cheung, Y, Dostmann, W, Pozzan, T, Kass, D, Paolocci, N, Houslay, MD, Zaccolo, M
Format:	Journal article
Idioma:	English
Publicat:	2006

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