Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

beta-Adrenergic signaling via cAMP generation and PKA activation mediates the positive inotropic effect of catecholamines on heart cells. Given the large diversity of protein kinase A targets within cardiac cells, a precisely regulated and confined activity of such signaling pathway is essential for...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Mongillo, M, Tocchetti, C, Terrin, A, Lissandron, V, Cheung, Y, Dostmann, W, Pozzan, T, Kass, D, Paolocci, N, Houslay, MD, Zaccolo, M
Format:	Journal article
Język:	English
Wydane:	2006

Podobne zapisy

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
od: Takimoto, E, i wsp.
Wydane: (2005)

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
od: Mongillo, M, i wsp.
Wydane: (2004)

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology.
od: Zaccolo, M, i wsp.
Wydane: (2007)

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
od: Bilal M. Qureshi, i wsp.
Wydane: (2018-08-01)

Phosphodiesterases and compartmentalized cAMP signalling in the heart.
od: Zaccolo, M
Wydane: (2006)

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
od: Terrin, A, i wsp.
Wydane: (2006)

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii
od: Kim Chi Vo, i wsp.
Wydane: (2022-01-01)

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
od: John F. Harms, i wsp.
Wydane: (2019-08-01)

cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.
od: Santiago A Plano, i wsp.
Wydane: (2012-01-01)

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia
od: Nadja I. Bork, i wsp.
Wydane: (2021-12-01)

cGMP-phosphodiesterase inhibition prevents hypoxia-induced cell death activation in porcine retinal explants
od: Olivares-González, L, i wsp.
Wydane: (2016)

Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes
od: Nadja I. Bork, i wsp.
Wydane: (2023-12-01)

Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.
od: Walid Mokni, i wsp.
Wydane: (2010-01-01)

Sub-nanomolar sensitivity of nitric oxide mediated regulation of cGMP and vasomotor reactivity in vascular smooth muscle
od: Kara F. Held, i wsp.
Wydane: (2012-07-01)

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture
od: Maria Faleeva, i wsp.
Wydane: (2022-10-01)

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.
od: Lomas, O, i wsp.
Wydane: (2014)

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.
od: Stangherlin, A, i wsp.
Wydane: (2012)

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
od: Baliga, RS, i wsp.
Wydane: (2018)

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
od: Jennifer Foulke-Abel, i wsp.
Wydane: (2020-11-01)

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk
od: Roberta Kurelic, i wsp.
Wydane: (2021-10-01)

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.
od: Lissandron, V, i wsp.
Wydane: (2006)

Measuring dynamic changes in cAMP using fluorescence resonance energy transfer.
od: Evellin, S, i wsp.
Wydane: (2004)

Study of cyclic adenosine monophosphate microdomains in cells.
od: Mongillo, M, i wsp.
Wydane: (2005)

NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.
od: Herring, N, i wsp.
Wydane: (2001)

Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
od: Musialek, P, i wsp.
Wydane: (2000)

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G
od: Pilar Monfort, i wsp.
Wydane: (2004-02-01)

Modulation of compartmentalized cyclic nucleotide signalling via local inhibition of phosphodiesterase activity
od: Brescia, M, i wsp.
Wydane: (2016)

Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis
od: Elisabeth Schinner, i wsp.
Wydane: (2017-04-01)

Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling
od: Zaccolo, M, i wsp.
Wydane: (2006)

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling.
od: Zaccolo, M, i wsp.
Wydane: (2006)

A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes
od: Mongillo, M, i wsp.
Wydane: (2006)

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.
od: Mongillo, M, i wsp.
Wydane: (2006)

Elevated retinal cGMP is not associated with elevated circulating cGMP levels in a canine model of retinitis pigmentosa.
od: Laurence M Occelli, i wsp.
Wydane: (2022-01-01)

Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation.
od: Martin, SR, i wsp.
Wydane: (2006)

Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway
od: Wisanee Wisanwattana, i wsp.
Wydane: (2021-03-01)

cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.
od: Stangherlin, A, i wsp.
Wydane: (2012)

NO-cGMP pathway increases the hyperpolarisation-activated current (I-f) and heart rate during adrenergic stimulation in the guinea-pig in vitro
od: Herring, N, i wsp.
Wydane: (2001)

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
od: Stangherlin, A, i wsp.
Wydane: (2011)

NO-cGMP pathway facilitates vagal neurotransmission and bradycardia
od: Herring, N, i wsp.
Wydane: (2001)

Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP
od: Ernesto Fedele, i wsp.
Wydane: (2021-01-01)