Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae).
Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797064787747667968 |
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| author | Kazimírová, M Sulanová, M Kozánek, M Takác, P Labuda, M Nuttall, P |
| author_facet | Kazimírová, M Sulanová, M Kozánek, M Takác, P Labuda, M Nuttall, P |
| author_sort | Kazimírová, M |
| collection | OXFORD |
| description | Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities. |
| first_indexed | 2024-03-06T21:19:22Z |
| format | Journal article |
| id | oxford-uuid:40e9f7db-7d42-46c8-8ae8-f205552022ac |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:19:22Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:40e9f7db-7d42-46c8-8ae8-f205552022ac2022-03-26T14:40:36ZIdentification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:40e9f7db-7d42-46c8-8ae8-f205552022acEnglishSymplectic Elements at Oxford2001Kazimírová, MSulanová, MKozánek, MTakác, PLabuda, MNuttall, PAnticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities. |
| spellingShingle | Kazimírová, M Sulanová, M Kozánek, M Takác, P Labuda, M Nuttall, P Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title | Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title_full | Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title_fullStr | Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title_full_unstemmed | Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title_short | Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae). |
| title_sort | identification of anticoagulant activities in salivary gland extracts of four horsefly species diptera tabanidae |
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