Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.
Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1826269077759328256 |
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| author | Swainson, R Rogers, R Sahakian, B Summers, B Polkey, C Robbins, T |
| author_facet | Swainson, R Rogers, R Sahakian, B Summers, B Polkey, C Robbins, T |
| author_sort | Swainson, R |
| collection | OXFORD |
| description | Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. |
| first_indexed | 2024-03-06T21:19:25Z |
| format | Journal article |
| id | oxford-uuid:40ed2eb3-4958-414d-a31c-bcceac7485ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:19:25Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:40ed2eb3-4958-414d-a31c-bcceac7485ad2022-03-26T14:40:41ZProbabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:40ed2eb3-4958-414d-a31c-bcceac7485adEnglishSymplectic Elements at Oxford2000Swainson, RRogers, RSahakian, BSummers, BPolkey, CRobbins, TThree groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. |
| spellingShingle | Swainson, R Rogers, R Sahakian, B Summers, B Polkey, C Robbins, T Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title | Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title_full | Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title_fullStr | Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title_full_unstemmed | Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title_short | Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. |
| title_sort | probabilistic learning and reversal deficits in patients with parkinson s disease or frontal or temporal lobe lesions possible adverse effects of dopaminergic medication |
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