C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations...

Bibliografski detalji
Glavni autori:	Di Genua, C, Valletta, S, Buono, M, Stoilova, B, Sweeney, C, Rodriguez-Meira, A, Grover, A, Meng, Y, Beveridge, R, Aboukhalil, Z, Karamitros, D, Belderbos, ME, Bystykh, L, Thongjuea, S, Vyas, P, Nerlov, C
Format:	Journal article
Jezik:	English
Izdano:	Cell Press 2020

Slični predmeti

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od: di Genua, C, i dr.
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od: Rodriguez, P, i dr.
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od: Mancini, E, i dr.
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od: Mancini, E, i dr.
Izdano: (2012)

Characterisation erythroid-specific cis-elements regulating the key transcription factor GATA1.
od: Drissen, R, i dr.
Izdano: (2006)

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od: Strouboulis, J, i dr.
Izdano: (2004)

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od: Rodriguez, P, i dr.
Izdano: (2005)

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od: Ashley C. Kramer, i dr.
Izdano: (2017-02-01)

Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression.
od: Drissen, R, i dr.
Izdano: (2010)

Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system
od: Deepti Jain, i dr.
Izdano: (2015-06-01)

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od: Pregernig, Gabriela
Izdano: (2017)

Dynamics of the Epigenetic Landscape During Erythroid Differentiation after Gata1 Restoration
od: Wu, Weisheng, i dr.
Izdano: (2012)

An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.
od: Whyatt, D, i dr.
Izdano: (2000)

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
od: Grover, A, i dr.
Izdano: (2014)

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od: Rodriguez, P, i dr.
Izdano: (2005)

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od: Chibuike David Obi, i dr.
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Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1
od: Long Liang, i dr.
Izdano: (2019-11-01)

Understanding erythroid differentiation
od: Higgs, D, i dr.
Izdano: (1993)

GATA1 and PU.1 Bind to Ribosomal Protein Genes in Erythroid Cells: Implications for Ribosomopathies.
od: Elsa P Amanatiadou, i dr.
Izdano: (2015-01-01)

Hematopoietic regulation of transcription factor GATA1 and mutations causing hereditary erythroid and megakaryocytic disorders
od: Biying DING, i dr.
Izdano: (2023-01-01)

Dicer is selectively important for the earliest stages of erythroid development.
od: Buza-Vidas, N, i dr.
Izdano: (2012)

MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment
od: Zhang, L., i dr.
Izdano: (2014)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
od: Funnell, A, i dr.
Izdano: (2014)

Cellular Reprogramming toward the Erythroid Lineage
od: Laura J. Norton, i dr.
Izdano: (2011-01-01)

Immunoregulation role of the erythroid cells
od: Chunxiao Niu, i dr.
Izdano: (2024-10-01)

Ferroportin and Erythroid Cells: An Update
od: Luciano Cianetti, i dr.
Izdano: (2010-01-01)

Non-erythroid effects of erythropoietin
od: Murat O. Arcasoy
Izdano: (2010-11-01)

A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy
od: Monika Gothwal, i dr.
Izdano: (2016-09-01)

Expression profile of healthy erythroid progenitors
od: Merryweather-Clarke, A, i dr.
Izdano: (2007)

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
od: Psaila, B, i dr.
Izdano: (2016)

IRON-METABOLISM IN TRANSFORMED ERYTHROID-CELLS
od: Rutherford, T, i dr.
Izdano: (1980)

Reorganisation of chromatin during erythroid differentiation
od: A. A. Khabarova, i dr.
Izdano: (2019-02-01)

Antitumor properties of nuclear erythroid cells
od: V. A. Kozlov, i dr.
Izdano: (2022-06-01)

The ins and outs of erythroid heme transport
od: Chang Cao, i dr.
Izdano: (2015-06-01)

EML Erythroid and Neutrophil Differentiation Protocols
od: Cristina Pina, i dr.
Izdano: (2014-06-01)

Matrix Mechanosensation in the Erythroid and Megakaryocytic Lineages
od: Christina M. Ward, i dr.
Izdano: (2020-04-01)

NSD1 in erythroid differentiation and leukemogenesis
od: Samantha Tauchmann, i dr.
Izdano: (2020-11-01)

Autopsy findings of acute erythroid leukemia
od: Mayur Parkhi, i dr.
Izdano: (2023-05-01)

Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression
od: Timothy M. Chlon, i dr.
Izdano: (2015-05-01)

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od: Ping Chun Wu, i dr.
Izdano: (2023-08-01)