Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient
Post-transplant lymphoproliferative disease (PTLD) can arise as a complication after solid organ transplantation. Epstein-Barr virus (EBV) infection is a known risk factor and is known to drive disease manifestation. PTLD can occur in EBV-negative recipients and with EBV-negative donor organs, howev...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Cureus
2021
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| _version_ | 1826269095201341440 |
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| author | Lee, C Vincentelli, H Visuri, J Knight, S Ploeg, R |
| author_facet | Lee, C Vincentelli, H Visuri, J Knight, S Ploeg, R |
| author_sort | Lee, C |
| collection | OXFORD |
| description | Post-transplant lymphoproliferative disease (PTLD) can arise as a complication after solid organ transplantation. Epstein-Barr virus (EBV) infection is a known risk factor and is known to drive disease manifestation. PTLD can occur in EBV-negative recipients and with EBV-negative donor organs, however, EBV-negative PTLD pathogenesis is unknown. Here, we present PTLD presenting as intussusception in a patient with a historic simultaneous pancreas-kidney transplant (SPK). This case study presents the first documented case of EBV-negative post-transplant lymphoproliferative disease in an EBV-seropositive SPK recipient from an EBV-positive donor. Here we describe the diagnosis and management of this patient, discuss the differences between EBV positive and negative driven post-transplant lymphoproliferative disease, and highlight areas of research opportunity in the latter. |
| first_indexed | 2024-03-06T21:19:41Z |
| format | Journal article |
| id | oxford-uuid:4105c5e3-3daa-4ed6-9ac9-258ffcfd5c67 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:19:41Z |
| publishDate | 2021 |
| publisher | Cureus |
| record_format | dspace |
| spelling | oxford-uuid:4105c5e3-3daa-4ed6-9ac9-258ffcfd5c672022-03-26T14:41:12ZEpstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipientJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4105c5e3-3daa-4ed6-9ac9-258ffcfd5c67EnglishSymplectic ElementsCureus2021Lee, CVincentelli, HVisuri, JKnight, SPloeg, RPost-transplant lymphoproliferative disease (PTLD) can arise as a complication after solid organ transplantation. Epstein-Barr virus (EBV) infection is a known risk factor and is known to drive disease manifestation. PTLD can occur in EBV-negative recipients and with EBV-negative donor organs, however, EBV-negative PTLD pathogenesis is unknown. Here, we present PTLD presenting as intussusception in a patient with a historic simultaneous pancreas-kidney transplant (SPK). This case study presents the first documented case of EBV-negative post-transplant lymphoproliferative disease in an EBV-seropositive SPK recipient from an EBV-positive donor. Here we describe the diagnosis and management of this patient, discuss the differences between EBV positive and negative driven post-transplant lymphoproliferative disease, and highlight areas of research opportunity in the latter. |
| spellingShingle | Lee, C Vincentelli, H Visuri, J Knight, S Ploeg, R Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title | Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title_full | Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title_fullStr | Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title_full_unstemmed | Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title_short | Epstein-Barr virus-negative diffuse large B-cell post-transplant lymphoma in an Epstein-Barr virus-positive recipient |
| title_sort | epstein barr virus negative diffuse large b cell post transplant lymphoma in an epstein barr virus positive recipient |
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