Centrosome amplification and cancer: A question of sufficiency.

Centrosome amplification and cancer: A question of sufficiency.

Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient to initiate tumorigenesis in a mouse model.

ग्रंथसूची विवरण
मुख्य लेखकों:	Raff, J, Basto, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Elsevier 2017

समान संसाधन

Centrosome amplification can initiate tumorigenesis in flies.
द्वारा: Basto, R, और अन्य
प्रकाशित: (2008)

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.
द्वारा: Baumbach, J, और अन्य
प्रकाशित: (2012)

Centrosomes and cancer: lessons from a TACC.
द्वारा: Raff, J
प्रकाशित: (2002)

Centrosomes: Central no more?
द्वारा: Raff, J
प्रकाशित: (2001)

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
द्वारा: Janina Baumbach, और अन्य
प्रकाशित: (2012-08-01)

HTLV-1 Tax: centrosome amplification and cancer
द्वारा: Kashanchi Fatah, और अन्य
प्रकाशित: (2006-08-01)

Centrosomes and microtubules: wedded with a ring.
द्वारा: Raff, J
प्रकाशित: (1996)

A Clinical Overview of Centrosome Amplification in Human Cancers
द्वारा: Jason Yongsheng Chan
प्रकाशित: (2011-01-01)

Phase separation and the centrosome: a fait accompli?
द्वारा: Raff, J
प्रकाशित: (2019)

The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division.
द्वारा: Butcher, R, और अन्य
प्रकाशित: (2004)

Centrioles, centrosomes, and cilia in health and disease.
द्वारा: Nigg, E, और अन्य
प्रकाशित: (2009)

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.
द्वारा: Barros, T, और अन्य
प्रकाशित: (2005)

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
द्वारा: Carolin M. Sauer, और अन्य
प्रकाशित: (2023-10-01)

Centrosome function and assembly in animal cells
द्वारा: Conduit, P, और अन्य
प्रकाशित: (2015)

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
द्वारा: Chenggang Zhang, और अन्य
प्रकाशित: (2023-01-01)

Oncosuppressive functions of PIDD1 in response to centrosome amplification
द्वारा: Ilio Vitale, और अन्य
प्रकाशित: (2021-02-01)

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
द्वारा: Zamora Ruben, और अन्य
प्रकाशित: (2010-08-01)

The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
द्वारा: Saavedra Harold I, और अन्य
प्रकाशित: (2011-01-01)

Patterns of selection against centrosome amplification in human cell lines.
द्वारा: Marco António Dias Louro, और अन्य
प्रकाशित: (2021-05-01)

Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors
द्वारा: Olivier Mercey, और अन्य
प्रकाशित: (2019-09-01)

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.
द्वारा: Conduit, P, और अन्य
प्रकाशित: (2014)

Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics.
द्वारा: Conduit, P, और अन्य
प्रकाशित: (2015)

The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.
द्वारा: Aashirwad Shahi, और अन्य
प्रकाशित: (2022-01-01)

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
द्वारा: Anatoliy Shumilov, और अन्य
प्रकाशित: (2017-02-01)

LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes.
द्वारा: Kidd, D, और अन्य
प्रकाशित: (1997)

Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer
द्वारा: Ashok Singh, और अन्य
प्रकाशित: (2020-08-01)

Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos.
द्वारा: Wakefield, J, और अन्य
प्रकाशित: (2000)

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
द्वारा: Berenjeno, I, और अन्य
प्रकाशित: (2017)

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
द्वारा: Inma M. Berenjeno, और अन्य
प्रकाशित: (2017-11-01)

Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome.
द्वारा: Bernardo P de Almeida, और अन्य
प्रकाशित: (2019-03-01)

Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.
द्वारा: Conduit, P, और अन्य
प्रकाशित: (2010)

Structural basis for mitotic centrosome assembly in flies
द्वारा: Feng, Z, और अन्य
प्रकाशित: (2017)

LK6, a novel Drosophila protein kinase that is rapidly turned over and is associated with microtubules and centrosomes.
द्वारा: Kidd, D, और अन्य
प्रकाशित: (1996)

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
द्वारा: Amato Angela, और अन्य
प्रकाशित: (2006-09-01)

MPS1 is involved in the HPV16-E7-mediated centrosomes amplification
द्वारा: Yair Alfaro-Mora, और अन्य
प्रकाशित: (2021-11-01)

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour
द्वारा: Lee, M, और अन्य
प्रकाशित: (2001)

A positive feedback loop drives centrosome maturation in flies
द्वारा: Alvarez Rodrigo, I, और अन्य
प्रकाशित: (2018)

The centrosomal protein CP190 regulates myosin function during early Drosophila development.
द्वारा: Chodagam, S, और अन्य
प्रकाशित: (2005)

Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.
द्वारा: Mary Kathryn Harrison Pitner, और अन्य
प्रकाशित: (2013-01-01)

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
द्वारा: Gergely, F, और अन्य
प्रकाशित: (2000)