Centrosome amplification and cancer: A question of sufficiency.

Centrosome amplification and cancer: A question of sufficiency.

Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient to initiate tumorigenesis in a mouse model.

Manylion Llyfryddiaeth
Prif Awduron:	Raff, J, Basto, R
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Elsevier 2017

Eitemau Tebyg

Centrosome amplification can initiate tumorigenesis in flies.
gan: Basto, R, et al.
Cyhoeddwyd: (2008)

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.
gan: Baumbach, J, et al.
Cyhoeddwyd: (2012)

Centrosomes and cancer: lessons from a TACC.
gan: Raff, J
Cyhoeddwyd: (2002)

Centrosomes: Central no more?
gan: Raff, J
Cyhoeddwyd: (2001)

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
gan: Janina Baumbach, et al.
Cyhoeddwyd: (2012-08-01)

HTLV-1 Tax: centrosome amplification and cancer
gan: Kashanchi Fatah, et al.
Cyhoeddwyd: (2006-08-01)

A Clinical Overview of Centrosome Amplification in Human Cancers
gan: Jason Yongsheng Chan
Cyhoeddwyd: (2011-01-01)

Centrosomes and microtubules: wedded with a ring.
gan: Raff, J
Cyhoeddwyd: (1996)

Phase separation and the centrosome: a fait accompli?
gan: Raff, J
Cyhoeddwyd: (2019)

The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division.
gan: Butcher, R, et al.
Cyhoeddwyd: (2004)

Centrioles, centrosomes, and cilia in health and disease.
gan: Nigg, E, et al.
Cyhoeddwyd: (2009)

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
gan: Carolin M. Sauer, et al.
Cyhoeddwyd: (2023-10-01)

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.
gan: Barros, T, et al.
Cyhoeddwyd: (2005)

Centrosome function and assembly in animal cells
gan: Conduit, P, et al.
Cyhoeddwyd: (2015)

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4
gan: Chenggang Zhang, et al.
Cyhoeddwyd: (2023-01-01)

Oncosuppressive functions of PIDD1 in response to centrosome amplification
gan: Ilio Vitale, et al.
Cyhoeddwyd: (2021-02-01)

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
gan: Zamora Ruben, et al.
Cyhoeddwyd: (2010-08-01)

The G<sub>1 </sub>phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
gan: Saavedra Harold I, et al.
Cyhoeddwyd: (2011-01-01)

Patterns of selection against centrosome amplification in human cell lines.
gan: Marco António Dias Louro, et al.
Cyhoeddwyd: (2021-05-01)

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.
gan: Conduit, P, et al.
Cyhoeddwyd: (2014)

Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics.
gan: Conduit, P, et al.
Cyhoeddwyd: (2015)

The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.
gan: Aashirwad Shahi, et al.
Cyhoeddwyd: (2022-01-01)

LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes.
gan: Kidd, D, et al.
Cyhoeddwyd: (1997)

Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos.
gan: Wakefield, J, et al.
Cyhoeddwyd: (2000)

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
gan: Berenjeno, I, et al.
Cyhoeddwyd: (2017)

Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome.
gan: Bernardo P de Almeida, et al.
Cyhoeddwyd: (2019-03-01)

Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.
gan: Conduit, P, et al.
Cyhoeddwyd: (2010)

Structural basis for mitotic centrosome assembly in flies
gan: Feng, Z, et al.
Cyhoeddwyd: (2017)

LK6, a novel Drosophila protein kinase that is rapidly turned over and is associated with microtubules and centrosomes.
gan: Kidd, D, et al.
Cyhoeddwyd: (1996)

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
gan: Amato Angela, et al.
Cyhoeddwyd: (2006-09-01)

MPS1 is involved in the HPV16-E7-mediated centrosomes amplification
gan: Yair Alfaro-Mora, et al.
Cyhoeddwyd: (2021-11-01)

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour
gan: Lee, M, et al.
Cyhoeddwyd: (2001)

A positive feedback loop drives centrosome maturation in flies
gan: Alvarez Rodrigo, I, et al.
Cyhoeddwyd: (2018)

Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.
gan: Mary Kathryn Harrison Pitner, et al.
Cyhoeddwyd: (2013-01-01)

The centrosomal protein CP190 regulates myosin function during early Drosophila development.
gan: Chodagam, S, et al.
Cyhoeddwyd: (2005)

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
gan: Gergely, F, et al.
Cyhoeddwyd: (2000)

Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM.
gan: Conduit, P, et al.
Cyhoeddwyd: (2010)

KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer
gan: Kening Zhou, et al.
Cyhoeddwyd: (2024-09-01)

Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules
gan: Hyun-Jin Na, et al.
Cyhoeddwyd: (2024-12-01)

A molecular mechanism of mitotic centrosome assembly in Drosophila
gan: Conduit, PT, et al.
Cyhoeddwyd: (2014)