Breast cancer cells interact with osteoblasts to support osteoclast formation.

Breast cancers commonly cause osteolytic metastases in bone, a process that is dependent upon osteoclast-mediated bone resorption. Recently the osteoclast differentiation factor (ODF), better termed RANKL (receptor activator of NF-kappaB ligand), expressed by osteoblasts has been cloned as well as i...

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Detalles Bibliográficos
Main Authors: Thomas, R, Guise, T, Yin, J, Elliott, J, Horwood, N, Martin, T, Gillespie, M
Formato: Journal article
Idioma:English
Publicado: 1999