A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

<jats:p>Potassium (K<jats:sup>+</jats:sup>) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) tha...

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Hlavní autoři: Schewe, M, Sun, H, Mert, Ü, Mackenzie, A, Pike, A, Schulz, F, Constantin, C, Vowinkel, K, Conrad, L, Kiper, A, Gonzalez, W, Musinszki, M, Tegtmeier, M, Pryde, D, Belabed, H, Nazare, M, De Groot, B, Decher, N, Fakler, B, Carpenter, E, Tucker, S, Baukrowitz, T
Médium: Journal article
Jazyk:English
Vydáno: American Association for the Advancement of Science 2019

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