Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1.
Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue, NRAMP1, i...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797064861359800320 |
|---|---|
| author | Dunstan, S Ho, V Duc, C Lanh, M Phuong, C Luxemburger, C Wain, J Dudbridge, F Peacock, C House, D Parry, C Hien, T Dougan, G Farrar, J Blackwell, J |
| author_facet | Dunstan, S Ho, V Duc, C Lanh, M Phuong, C Luxemburger, C Wain, J Dudbridge, F Peacock, C House, D Parry, C Hien, T Dougan, G Farrar, J Blackwell, J |
| author_sort | Dunstan, S |
| collection | OXFORD |
| description | Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue, NRAMP1, in resistance to typhoid fever in southern Vietnam. Patients with blood-culture-confirmed typhoid fever and healthy control subjects were genotyped for 6 polymorphic markers within and near NRAMP1 on chromosome 2q35. Four single base-pair polymorphisms (274 C/T, 469+14 G/C, 1465-85 G/A, and D543N), a (GT)(n) repeat in the promoter region of NRAMP1 and D2S1471, and a microsatellite marker approximately 130-kb downstream of NRAMP1 were examined. The allelic and genotypic frequencies for each polymorphism were compared in case patients and control subjects. No allelic association was identified between the NRAMP1 alleles and typhoid fever susceptibility. In addition, neither homozygotes nor heterozygotes for any NRAMP1 variants were at increased risk of typhoid fever. |
| first_indexed | 2024-03-06T21:20:26Z |
| format | Journal article |
| id | oxford-uuid:41439ebc-034a-4ec6-a2b6-5b25c7108f22 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:20:26Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:41439ebc-034a-4ec6-a2b6-5b25c7108f222022-03-26T14:42:38ZTyphoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:41439ebc-034a-4ec6-a2b6-5b25c7108f22EnglishSymplectic Elements at Oxford2001Dunstan, SHo, VDuc, CLanh, MPhuong, CLuxemburger, CWain, JDudbridge, FPeacock, CHouse, DParry, CHien, TDougan, GFarrar, JBlackwell, JControl of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue, NRAMP1, in resistance to typhoid fever in southern Vietnam. Patients with blood-culture-confirmed typhoid fever and healthy control subjects were genotyped for 6 polymorphic markers within and near NRAMP1 on chromosome 2q35. Four single base-pair polymorphisms (274 C/T, 469+14 G/C, 1465-85 G/A, and D543N), a (GT)(n) repeat in the promoter region of NRAMP1 and D2S1471, and a microsatellite marker approximately 130-kb downstream of NRAMP1 were examined. The allelic and genotypic frequencies for each polymorphism were compared in case patients and control subjects. No allelic association was identified between the NRAMP1 alleles and typhoid fever susceptibility. In addition, neither homozygotes nor heterozygotes for any NRAMP1 variants were at increased risk of typhoid fever. |
| spellingShingle | Dunstan, S Ho, V Duc, C Lanh, M Phuong, C Luxemburger, C Wain, J Dudbridge, F Peacock, C House, D Parry, C Hien, T Dougan, G Farrar, J Blackwell, J Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title | Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title_full | Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title_fullStr | Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title_full_unstemmed | Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title_short | Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. |
| title_sort | typhoid fever and genetic polymorphisms at the natural resistance associated macrophage protein 1 |
| work_keys_str_mv | AT dunstans typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT hov typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT ducc typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT lanhm typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT phuongc typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT luxemburgerc typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT wainj typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT dudbridgef typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT peacockc typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT housed typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT parryc typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT hient typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT dougang typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT farrarj typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 AT blackwellj typhoidfeverandgeneticpolymorphismsatthenaturalresistanceassociatedmacrophageprotein1 |