Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective
In the last decade, autoantibodies targeting proteins on the neuronal surface and that are believed to be directly pathogenic have been described in patients with autoimmune encephalitis. Since then, new antigenic targets have been discovered, and new clinical phenotypes have been recognized. The ps...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797064872028012544 |
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| author | Coutinho, E Harrison, P Vincent, A |
| author_facet | Coutinho, E Harrison, P Vincent, A |
| author_sort | Coutinho, E |
| collection | OXFORD |
| description | In the last decade, autoantibodies targeting proteins on the neuronal surface and that are believed to be directly pathogenic have been described in patients with autoimmune encephalitis. Since then, new antigenic targets have been discovered, and new clinical phenotypes have been recognized. The psychotic disorders are one example of this expanding spectrum. Here, we consider the defining criteria of antibody-mediated central nervous system disease and the extent to which the psychiatric data currently satisfy those criteria. We discuss the implications these findings have for our understanding, nosology, and treatment of psychiatric disorders. © 2014 Society of Biological Psychiatry. |
| first_indexed | 2024-03-06T21:20:35Z |
| format | Journal article |
| id | oxford-uuid:414ed471-921e-4d03-9b20-8d5bbaa691c2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:20:35Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:414ed471-921e-4d03-9b20-8d5bbaa691c22022-03-26T14:42:56ZDo neuronal autoantibodies cause psychosis? a neuroimmunological perspectiveJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:414ed471-921e-4d03-9b20-8d5bbaa691c2EnglishSymplectic Elements at Oxford2014Coutinho, EHarrison, PVincent, AIn the last decade, autoantibodies targeting proteins on the neuronal surface and that are believed to be directly pathogenic have been described in patients with autoimmune encephalitis. Since then, new antigenic targets have been discovered, and new clinical phenotypes have been recognized. The psychotic disorders are one example of this expanding spectrum. Here, we consider the defining criteria of antibody-mediated central nervous system disease and the extent to which the psychiatric data currently satisfy those criteria. We discuss the implications these findings have for our understanding, nosology, and treatment of psychiatric disorders. © 2014 Society of Biological Psychiatry. |
| spellingShingle | Coutinho, E Harrison, P Vincent, A Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title | Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title_full | Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title_fullStr | Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title_full_unstemmed | Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title_short | Do neuronal autoantibodies cause psychosis? a neuroimmunological perspective |
| title_sort | do neuronal autoantibodies cause psychosis a neuroimmunological perspective |
| work_keys_str_mv | AT coutinhoe doneuronalautoantibodiescausepsychosisaneuroimmunologicalperspective AT harrisonp doneuronalautoantibodiescausepsychosisaneuroimmunologicalperspective AT vincenta doneuronalautoantibodiescausepsychosisaneuroimmunologicalperspective |