Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflammatory bowel disease (IBD). A vital cytokine in regulating intestinal T cells is transforming growth factor-β (TGFβ), which is secreted by cells as a latent complex that requires activation to functio...

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Bibliografiske detaljer
Main Authors:	Fenton, T, Kelly, A, Shuttleworth, E, Smedley, C, Atakilit, A, Powrie, F, Campbell, S, Nishimura, S, Sheppard, D, Levison, S, Worthington, J, Lehtinen, M, Travis, M
Format:	Journal article
Sprog:	English
Udgivet:	Springer Nature 2016

Lignende værker

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af: Worthington, J, et al.
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af: Bryan Vander Lugt, et al.
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af: Leonie Schittenhelm, et al.
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