A "reverse pharmacology" approach for developing an anti-malarial phytomedicine.
A "reverse pharmacology" approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-ou...
| المؤلفون الرئيسيون: | , , , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
BioMed Central
2011
|
| _version_ | 1826269188717543424 |
|---|---|
| author | Willcox, M Graz, B Falquet, J Diakite, C Giani, S Diallo, D |
| author_facet | Willcox, M Graz, B Falquet, J Diakite, C Giani, S Diallo, D |
| author_sort | Willcox, M |
| collection | OXFORD |
| description | A "reverse pharmacology" approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of "reverse pharmacology" shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered. |
| first_indexed | 2024-03-06T21:21:09Z |
| format | Journal article |
| id | oxford-uuid:417c7a4c-3cc7-4de1-918f-d6d6a9d93078 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:21:09Z |
| publishDate | 2011 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:417c7a4c-3cc7-4de1-918f-d6d6a9d930782022-03-26T14:43:56ZA "reverse pharmacology" approach for developing an anti-malarial phytomedicine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:417c7a4c-3cc7-4de1-918f-d6d6a9d93078EnglishSymplectic Elements at OxfordBioMed Central2011Willcox, MGraz, BFalquet, JDiakite, CGiani, SDiallo, DA "reverse pharmacology" approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of "reverse pharmacology" shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered. |
| spellingShingle | Willcox, M Graz, B Falquet, J Diakite, C Giani, S Diallo, D A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title | A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title_full | A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title_fullStr | A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title_full_unstemmed | A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title_short | A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. |
| title_sort | reverse pharmacology approach for developing an anti malarial phytomedicine |
| work_keys_str_mv | AT willcoxm areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT grazb areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT falquetj areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT diakitec areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT gianis areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT diallod areversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT willcoxm reversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT grazb reversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT falquetj reversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT diakitec reversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT gianis reversepharmacologyapproachfordevelopinganantimalarialphytomedicine AT diallod reversepharmacologyapproachfordevelopinganantimalarialphytomedicine |