Host susceptibility to periodontitis: mapping murine genomic regions.
Host susceptibility to periodontal infection is controlled by genetic factors. As a step toward identifying and cloning these factors, we generated an A/J x BALB/cJ F2 mouse resource population. A genome-wide search for Quantitative Trait Loci (QTL) associated with periodontitis was performed. We ai...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826269207554162688 |
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| author | Shusterman, A Durrant, C Mott, R Polak, D Schaefer, A Weiss, E Iraqi, F Houri-Haddad, Y |
| author_facet | Shusterman, A Durrant, C Mott, R Polak, D Schaefer, A Weiss, E Iraqi, F Houri-Haddad, Y |
| author_sort | Shusterman, A |
| collection | OXFORD |
| description | Host susceptibility to periodontal infection is controlled by genetic factors. As a step toward identifying and cloning these factors, we generated an A/J x BALB/cJ F2 mouse resource population. A genome-wide search for Quantitative Trait Loci (QTL) associated with periodontitis was performed. We aimed to quantify the phenotypic response of the progenies to periodontitis by microCT analysis, to perform a genome-wide search for QTL associated with periodontitis, and, finally, to suggest candidate genes for periodontitis. We were able to produce 408 F2 mice. All mice were co-infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria. Six weeks following infection, alveolar bone loss was quantified by computerized tomography (microCT) technology. We found normal distribution of the phenotype, with 2 highly significant QTL on chromosomes 5 and 3. A third significant QTL was found on chromosome 1. Candidate genes were suggested, such as Toll-like receptors (TLR) 1 and 6, chemokines, and bone-remodeling genes (enamelin, ameloblastin, and amelotin). This report shows that periodontitis in mice is a polygenic trait with highly significant mapped QTL. |
| first_indexed | 2024-03-06T21:21:27Z |
| format | Journal article |
| id | oxford-uuid:41948bb3-a3a1-46fa-b4ec-b8e471799963 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:21:27Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:41948bb3-a3a1-46fa-b4ec-b8e4717999632022-03-26T14:44:32ZHost susceptibility to periodontitis: mapping murine genomic regions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:41948bb3-a3a1-46fa-b4ec-b8e471799963EnglishSymplectic Elements at Oxford2013Shusterman, ADurrant, CMott, RPolak, DSchaefer, AWeiss, EIraqi, FHouri-Haddad, YHost susceptibility to periodontal infection is controlled by genetic factors. As a step toward identifying and cloning these factors, we generated an A/J x BALB/cJ F2 mouse resource population. A genome-wide search for Quantitative Trait Loci (QTL) associated with periodontitis was performed. We aimed to quantify the phenotypic response of the progenies to periodontitis by microCT analysis, to perform a genome-wide search for QTL associated with periodontitis, and, finally, to suggest candidate genes for periodontitis. We were able to produce 408 F2 mice. All mice were co-infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria. Six weeks following infection, alveolar bone loss was quantified by computerized tomography (microCT) technology. We found normal distribution of the phenotype, with 2 highly significant QTL on chromosomes 5 and 3. A third significant QTL was found on chromosome 1. Candidate genes were suggested, such as Toll-like receptors (TLR) 1 and 6, chemokines, and bone-remodeling genes (enamelin, ameloblastin, and amelotin). This report shows that periodontitis in mice is a polygenic trait with highly significant mapped QTL. |
| spellingShingle | Shusterman, A Durrant, C Mott, R Polak, D Schaefer, A Weiss, E Iraqi, F Houri-Haddad, Y Host susceptibility to periodontitis: mapping murine genomic regions. |
| title | Host susceptibility to periodontitis: mapping murine genomic regions. |
| title_full | Host susceptibility to periodontitis: mapping murine genomic regions. |
| title_fullStr | Host susceptibility to periodontitis: mapping murine genomic regions. |
| title_full_unstemmed | Host susceptibility to periodontitis: mapping murine genomic regions. |
| title_short | Host susceptibility to periodontitis: mapping murine genomic regions. |
| title_sort | host susceptibility to periodontitis mapping murine genomic regions |
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