Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece.
The widespread use of antiviral drugs against HIV has increased the prevalence of HIV-1 resistant strains among naïve individuals due to transmission of resistant strains. The purpose of this study was to investigate the presence of HIV-1 strains harboring resistance mutations in naïve patients in G...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797064947695353856 |
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| author | Magiorkinis, E Paraskevis, D Magiorkinis, G Chryssou, S Chini, M Lazanas, M Paparizos, V Saroglou, G Antoniadou, A Giamarellou, E Karafoulidou, A Hatzakis, A |
| author_facet | Magiorkinis, E Paraskevis, D Magiorkinis, G Chryssou, S Chini, M Lazanas, M Paparizos, V Saroglou, G Antoniadou, A Giamarellou, E Karafoulidou, A Hatzakis, A |
| author_sort | Magiorkinis, E |
| collection | OXFORD |
| description | The widespread use of antiviral drugs against HIV has increased the prevalence of HIV-1 resistant strains among naïve individuals due to transmission of resistant strains. The purpose of this study was to investigate the presence of HIV-1 strains harboring resistance mutations in naïve patients in Greece. Blood samples were collected from 25 individuals. The DNA sequence of protease and partial reverse transcriptase regions (codons 41-223) were obtained by direct sequencing. Our results showed the absence of any primary resistance mutations in the study population. However, we were able to identify high prevalence of sequence polymorphisms at positions in reverse transcriptase region associated mainly with resistance to NNRTIs. Moreover, in protease region several secondary mutations were detected, suggesting the higher genetic variability of this region. The clinical significance of the polymorphisms associated with reduced susceptibility to NNRTIs remains to be clarified. |
| first_indexed | 2024-03-06T21:21:36Z |
| format | Journal article |
| id | oxford-uuid:41a1bea9-412e-4cd9-8d0f-8b41f1196ab5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:21:36Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:41a1bea9-412e-4cd9-8d0f-8b41f1196ab52022-03-26T14:44:54ZMutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:41a1bea9-412e-4cd9-8d0f-8b41f1196ab5EnglishSymplectic Elements at Oxford2002Magiorkinis, EParaskevis, DMagiorkinis, GChryssou, SChini, MLazanas, MPaparizos, VSaroglou, GAntoniadou, AGiamarellou, EKarafoulidou, AHatzakis, AThe widespread use of antiviral drugs against HIV has increased the prevalence of HIV-1 resistant strains among naïve individuals due to transmission of resistant strains. The purpose of this study was to investigate the presence of HIV-1 strains harboring resistance mutations in naïve patients in Greece. Blood samples were collected from 25 individuals. The DNA sequence of protease and partial reverse transcriptase regions (codons 41-223) were obtained by direct sequencing. Our results showed the absence of any primary resistance mutations in the study population. However, we were able to identify high prevalence of sequence polymorphisms at positions in reverse transcriptase region associated mainly with resistance to NNRTIs. Moreover, in protease region several secondary mutations were detected, suggesting the higher genetic variability of this region. The clinical significance of the polymorphisms associated with reduced susceptibility to NNRTIs remains to be clarified. |
| spellingShingle | Magiorkinis, E Paraskevis, D Magiorkinis, G Chryssou, S Chini, M Lazanas, M Paparizos, V Saroglou, G Antoniadou, A Giamarellou, E Karafoulidou, A Hatzakis, A Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title | Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title_full | Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title_fullStr | Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title_full_unstemmed | Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title_short | Mutations associated with genotypic resistance to antiretroviral therapy in treatment naive HIV-1 infected patients in Greece. |
| title_sort | mutations associated with genotypic resistance to antiretroviral therapy in treatment naive hiv 1 infected patients in greece |
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