5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the inc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1994
|
| _version_ | 1826269234825527296 |
|---|---|
| author | Jebb, SA Osborne, R Maughan, T Mohideen, N Mack, P Mort, D Shelley, MD Elia, M |
| author_facet | Jebb, SA Osborne, R Maughan, T Mohideen, N Mack, P Mort, D Shelley, MD Elia, M |
| author_sort | Jebb, SA |
| collection | OXFORD |
| description | In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity of cytotoxic-induced mucositis. This study examined the role of oral glutamine supplementation in the management of mucositis caused by 5-fluorouracil (5-FU) and folinic acid. Twenty-eight patients with gastrointestinal cancers were randomised to receive 16 g of glutamine per day for 8 days, or placebo, in a randomised double-blind trial before crossing over to the alternative supplement during the second treatment cycle. The supplement was well tolerated with no apparent adverse effects, but failed to have any significant effect on oral mucositis assessed by the patients or investigator. The possible reasons for this apparent lack of benefit are discussed. |
| first_indexed | 2024-03-06T21:21:52Z |
| format | Journal article |
| id | oxford-uuid:41b66e58-859d-4160-b324-f3b7311982d7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:21:52Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:41b66e58-859d-4160-b324-f3b7311982d72022-03-26T14:45:20Z5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:41b66e58-859d-4160-b324-f3b7311982d7EnglishSymplectic Elements at Oxford1994Jebb, SAOsborne, RMaughan, TMohideen, NMack, PMort, DShelley, MDElia, MIn some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity of cytotoxic-induced mucositis. This study examined the role of oral glutamine supplementation in the management of mucositis caused by 5-fluorouracil (5-FU) and folinic acid. Twenty-eight patients with gastrointestinal cancers were randomised to receive 16 g of glutamine per day for 8 days, or placebo, in a randomised double-blind trial before crossing over to the alternative supplement during the second treatment cycle. The supplement was well tolerated with no apparent adverse effects, but failed to have any significant effect on oral mucositis assessed by the patients or investigator. The possible reasons for this apparent lack of benefit are discussed. |
| spellingShingle | Jebb, SA Osborne, R Maughan, T Mohideen, N Mack, P Mort, D Shelley, MD Elia, M 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title | 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title_full | 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title_fullStr | 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title_full_unstemmed | 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title_short | 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. |
| title_sort | 5 fluorouracil and folinic acid induced mucositis no effect of oral glutamine supplementation |
| work_keys_str_mv | AT jebbsa 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT osborner 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT maughant 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT mohideenn 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT mackp 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT mortd 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT shelleymd 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation AT eliam 5fluorouracilandfolinicacidinducedmucositisnoeffectoforalglutaminesupplementation |