CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis.

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis.

BACKGROUND: Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1G93A). Administration of non-targeted glucocorticoids...

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Bibliographic Details
Main Authors: Evans, M, Gaillard, P, de Boer, M, Appeldoorn, C, Dorland, R, Sibson, N, Turner, M, Anthony, D, Stolp, H
Format: Journal article
Language:English
Published: 2014

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