Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 is reported to catalyze hydroxylation of lysine residue(...
| Glavni autori: | , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2019
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