Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.

JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 is reported to catalyze hydroxylation of lysine residue(...

詳細記述

書誌詳細
主要な著者: Islam, MS, McDonough, MA, Chowdhury, R, Gault, J, Khan, A, Pires, E, Schofield, CJ
フォーマット: Journal article
言語:English
出版事項: American Society for Biochemistry and Molecular Biology 2019