Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.

JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 is reported to catalyze hydroxylation of lysine residue(...

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Detalhes bibliográficos
Main Authors: Islam, MS, McDonough, MA, Chowdhury, R, Gault, J, Khan, A, Pires, E, Schofield, CJ
Formato: Journal article
Idioma:English
Publicado em: American Society for Biochemistry and Molecular Biology 2019