Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variab...

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Autors principals: Luijk, R, Wu, H, Ward-Caviness, C, Hannon, E, Carnero-Montoro, E, Min, J, Mandaviya, P, Müller-Nurasyid, M, Mei, H, Van Der Maarel, S, BIOS Consortium, Relton, C, Mill, J, Waldenberger, M, Bell, J, Jansen, R, Zhernakova, A, Franke, L, 'T Hoen, P, Boomsma, D, Van Duijn, C, Van Greevenbroek, M, Veldink, J, Wijmenga, C, Van Meurs, J, Daxinger, L, Slagboom, P, Van Zwet, E, Heijmans, B
Format: Journal article
Idioma:English
Publicat: Nature Publishing Group 2018

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