From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks
One of the most visually striking patterns in the early developing embryo is somite segmentation. Somites form as repeated, periodic structures in pairs along nearly the entire caudal vertebrate axis. The morphological process involves short- and long-range signals that drive cell rearrangements and...
| Main Authors: | , , , , |
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| Format: | Journal article |
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2007
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| _version_ | 1797065084807151616 |
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| author | Kulesa, P Schnell, S Rudloff, S Baker, R Maini, P |
| author_facet | Kulesa, P Schnell, S Rudloff, S Baker, R Maini, P |
| author_sort | Kulesa, P |
| collection | OXFORD |
| description | One of the most visually striking patterns in the early developing embryo is somite segmentation. Somites form as repeated, periodic structures in pairs along nearly the entire caudal vertebrate axis. The morphological process involves short- and long-range signals that drive cell rearrangements and cell shaping to create discrete, epithelialized segments. Key to developing novel strategies to prevent somite birth defects that involve axial bone and skeletal muscle development is understanding how the molecular choreography is coordinated across multiple spatial scales and in a repeating temporal manner. Mathematical models have emerged as useful tools to integrate spatiotemporal data and simulate model mechanisms to provide unique insights into somite pattern formation. In this short review, we present two quantitative frameworks that address the morphogenesis from segment to somite and discuss recent data of segmentation and epithelialization. |
| first_indexed | 2024-03-06T21:23:35Z |
| format | Journal article |
| id | oxford-uuid:42524d65-405e-43da-8343-f2e2f5819a54 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:23:35Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:42524d65-405e-43da-8343-f2e2f5819a542022-03-26T14:48:45ZFrom segment to somite: segmentation to epithelialization analyzed within quantitative frameworksJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42524d65-405e-43da-8343-f2e2f5819a54Mathematical Institute - ePrints2007Kulesa, PSchnell, SRudloff, SBaker, RMaini, POne of the most visually striking patterns in the early developing embryo is somite segmentation. Somites form as repeated, periodic structures in pairs along nearly the entire caudal vertebrate axis. The morphological process involves short- and long-range signals that drive cell rearrangements and cell shaping to create discrete, epithelialized segments. Key to developing novel strategies to prevent somite birth defects that involve axial bone and skeletal muscle development is understanding how the molecular choreography is coordinated across multiple spatial scales and in a repeating temporal manner. Mathematical models have emerged as useful tools to integrate spatiotemporal data and simulate model mechanisms to provide unique insights into somite pattern formation. In this short review, we present two quantitative frameworks that address the morphogenesis from segment to somite and discuss recent data of segmentation and epithelialization. |
| spellingShingle | Kulesa, P Schnell, S Rudloff, S Baker, R Maini, P From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title | From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title_full | From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title_fullStr | From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title_full_unstemmed | From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title_short | From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks |
| title_sort | from segment to somite segmentation to epithelialization analyzed within quantitative frameworks |
| work_keys_str_mv | AT kulesap fromsegmenttosomitesegmentationtoepithelializationanalyzedwithinquantitativeframeworks AT schnells fromsegmenttosomitesegmentationtoepithelializationanalyzedwithinquantitativeframeworks AT rudloffs fromsegmenttosomitesegmentationtoepithelializationanalyzedwithinquantitativeframeworks AT bakerr fromsegmenttosomitesegmentationtoepithelializationanalyzedwithinquantitativeframeworks AT mainip fromsegmenttosomitesegmentationtoepithelializationanalyzedwithinquantitativeframeworks |