Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients.
We assayed cryopreserved sera from 38 acetylcholine receptor (AChR) antibody-negative patients with myasthenia gravis (MG) who were followed clinically for muscle-specific tyrosine kinase (MuSK) antibodies and analyzed and compared their clinical characteristics. None of 13 sera from patients with p...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797065135564521472 |
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| author | Zhou, L McConville, J Chaudhry, V Adams, R Skolasky, R Vincent, A Drachman, D |
| author_facet | Zhou, L McConville, J Chaudhry, V Adams, R Skolasky, R Vincent, A Drachman, D |
| author_sort | Zhou, L |
| collection | OXFORD |
| description | We assayed cryopreserved sera from 38 acetylcholine receptor (AChR) antibody-negative patients with myasthenia gravis (MG) who were followed clinically for muscle-specific tyrosine kinase (MuSK) antibodies and analyzed and compared their clinical characteristics. None of 13 sera from patients with purely ocular MG were positive. Sera from 10 of 25 patients (40%) with generalized MG were positive for MuSK antibodies. The age at onset of myasthenic symptoms was significantly earlier in MuSK antibody-positive patients (P = 0.02). MuSK antibodies were present in AChR antibody-negative patients of either gender, with virtually identical prevalence in women (41.2%) and men (37.5%). The distribution of weakness more commonly involved neck muscles in MuSK antibody-positive patients, and limb muscles in MuSK antibody-negative patients. Patients responded to immunosuppressive treatment regardless of whether MuSK antibody was present. We conclude that MuSK antibodies are present and diagnostically useful in a subset of myasthenic patients without AChR antibodies. Although the distribution of weakness differs somewhat depending on whether MuSK antibodies are present, responses to anticholinesterase and immunosuppressive treatments are similar. |
| first_indexed | 2024-03-06T21:24:19Z |
| format | Journal article |
| id | oxford-uuid:428e9a6d-0249-411c-90aa-2c4c46c23529 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:24:19Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:428e9a6d-0249-411c-90aa-2c4c46c235292022-03-26T14:50:11ZClinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:428e9a6d-0249-411c-90aa-2c4c46c23529EnglishSymplectic Elements at Oxford2004Zhou, LMcConville, JChaudhry, VAdams, RSkolasky, RVincent, ADrachman, DWe assayed cryopreserved sera from 38 acetylcholine receptor (AChR) antibody-negative patients with myasthenia gravis (MG) who were followed clinically for muscle-specific tyrosine kinase (MuSK) antibodies and analyzed and compared their clinical characteristics. None of 13 sera from patients with purely ocular MG were positive. Sera from 10 of 25 patients (40%) with generalized MG were positive for MuSK antibodies. The age at onset of myasthenic symptoms was significantly earlier in MuSK antibody-positive patients (P = 0.02). MuSK antibodies were present in AChR antibody-negative patients of either gender, with virtually identical prevalence in women (41.2%) and men (37.5%). The distribution of weakness more commonly involved neck muscles in MuSK antibody-positive patients, and limb muscles in MuSK antibody-negative patients. Patients responded to immunosuppressive treatment regardless of whether MuSK antibody was present. We conclude that MuSK antibodies are present and diagnostically useful in a subset of myasthenic patients without AChR antibodies. Although the distribution of weakness differs somewhat depending on whether MuSK antibodies are present, responses to anticholinesterase and immunosuppressive treatments are similar. |
| spellingShingle | Zhou, L McConville, J Chaudhry, V Adams, R Skolasky, R Vincent, A Drachman, D Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title | Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title_full | Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title_fullStr | Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title_full_unstemmed | Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title_short | Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. |
| title_sort | clinical comparison of muscle specific tyrosine kinase musk antibody positive and negative myasthenic patients |
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