The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.
The metabolic reduction of 11-keto groups in glucocorticoid steroids such as cortisone leads to the nuclear receptor ligand cortisol. This conversion is an example of pre-receptor regulation and constitutes a novel pharmacological target for the treatment of metabolic disorders such as insulin resis...
প্রধান লেখক: | Ogg, D, Elleby, B, Norström, C, Stefansson, K, Abrahmsén, L, Oppermann, U, Svensson, S |
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বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
2005
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.
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প্রকাশিত: (2003) -
High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.
অনুযায়ী: Elleby, B, অন্যান্য
প্রকাশিত: (2004) -
Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
অনুযায়ী: Hult, M, অন্যান্য
প্রকাশিত: (2004) -
Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome
অনুযায়ী: Oppermann, U, অন্যান্য
প্রকাশিত: (2003) -
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
অনুযায়ী: Hult, M, অন্যান্য
প্রকাশিত: (2006)