The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The metabolic reduction of 11-keto groups in glucocorticoid steroids such as cortisone leads to the nuclear receptor ligand cortisol. This conversion is an example of pre-receptor regulation and constitutes a novel pharmacological target for the treatment of metabolic disorders such as insulin resis...

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Bibliografiske detaljer
Main Authors:	Ogg, D, Elleby, B, Norström, C, Stefansson, K, Abrahmsén, L, Oppermann, U, Svensson, S
Format:	Journal article
Sprog:	English
Udgivet:	2005

Lignende værker

Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.
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Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome
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Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
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Heterogeneity of 11beta-hydroxysteroid dehydrogenase type 1/microsomal carbonyl reductase (11beta-HSD/CR) in guinea pig tissues. Purification of the liver form suggests modification in the cosubstrate binding site.
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Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
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The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
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Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
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Expression of gluconeogenic enzymes and 11β-hydroxysteroid dehydrogenase type 1 in liver of diabetic mice after acute exercise
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11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
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11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
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Structure-function relationships of SDR hydroxysteroid dehydrogenases.
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Structure-function relationships of 3 beta-hydroxysteroid dehydrogenases involved in bile acid metabolism.
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Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
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Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
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Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
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11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
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