The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The metabolic reduction of 11-keto groups in glucocorticoid steroids such as cortisone leads to the nuclear receptor ligand cortisol. This conversion is an example of pre-receptor regulation and constitutes a novel pharmacological target for the treatment of metabolic disorders such as insulin resis...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Ogg, D, Elleby, B, Norström, C, Stefansson, K, Abrahmsén, L, Oppermann, U, Svensson, S
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2005

Παρόμοια τεκμήρια

Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.
ανά: Shafqat, N, κ.ά.
Έκδοση: (2003)

High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.
ανά: Elleby, B, κ.ά.
Έκδοση: (2004)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
ανά: Hult, M, κ.ά.
Έκδοση: (2004)

Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome
ανά: Oppermann, U, κ.ά.
Έκδοση: (2003)

Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
ανά: Hult, M, κ.ά.
Έκδοση: (2006)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
ανά: Hult, M, κ.ά.
Έκδοση: (2001)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
ανά: Maser, E, κ.ά.
Έκδοση: (1997)

Heterogeneity of 11beta-hydroxysteroid dehydrogenase type 1/microsomal carbonyl reductase (11beta-HSD/CR) in guinea pig tissues. Purification of the liver form suggests modification in the cosubstrate binding site.
ανά: Oppermann, U, κ.ά.
Έκδοση: (2000)

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
ανά: Oppermann, U
Έκδοση: (2006)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1997)

Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1995)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
ανά: Lukacik, P, κ.ά.
Έκδοση: (2006)

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2001)

Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics.
ανά: Hult, M, κ.ά.
Έκδοση: (1998)

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.
ανά: Stulnig, T, κ.ά.
Έκδοση: (2002)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2000)

Molecular cloning and sequencing of mouse hepatic 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase. A member of the short chain dehydrogenase superfamily.
ανά: Maser, E, κ.ά.
Έκδοση: (1995)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
ανά: Stewart, P, κ.ά.
Έκδοση: (2002)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
ανά: Sinclair, A, κ.ά.
Έκδοση: (2007)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.
ανά: Davani, B, κ.ά.
Έκδοση: (2000)

The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action
ανά: Maser, E, κ.ά.
Έκδοση: (1997)

The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action
ανά: Maser, E, κ.ά.
Έκδοση: (1997)

Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids.
ανά: Marschall, H, κ.ά.
Έκδοση: (2000)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2010)

Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
ανά: Nordling, E, κ.ά.
Έκδοση: (2001)

Expression of gluconeogenic enzymes and 11β-hydroxysteroid dehydrogenase type 1 in liver of diabetic mice after acute exercise
ανά: Brust KB, κ.ά.
Έκδοση: (2014-10-01)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
ανά: Katarzyna Kosicka, κ.ά.
Έκδοση: (2016-01-01)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
ανά: Rauz, S, κ.ά.
Έκδοση: (2004)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
ανά: Morgan, SA, κ.ά.
Έκδοση: (2010)

Structure-function relationships of SDR hydroxysteroid dehydrogenases.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1997)

Structure-function relationships of 3 beta-hydroxysteroid dehydrogenases involved in bile acid metabolism.
ανά: Filling, C, κ.ά.
Έκδοση: (1999)

Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
ανά: Korbonits, M, κ.ά.
Έκδοση: (2001)

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1997)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2005)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2004)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
ανά: Tomlinson, J
Έκδοση: (2005)