An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

<p><strong>Objectives</strong> To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.</p> <p><strong>Methods</strong> We performed conditiona...

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Detalhes bibliográficos
Main Authors: Roberts, AR, Vecellio, M, Chen, L, Ridley, A, Cortes, A, Knight, JC, Bowness, P, Cohen, CJ, Wordsworth, BP
Formato: Journal article
Idioma:English
Publicado em: BMJ Publishing Group 2016

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