An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

<p><strong>Objectives</strong> To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.</p> <p><strong>Methods</strong> We performed conditiona...

Detaylı Bibliyografya
Asıl Yazarlar:	Roberts, AR, Vecellio, M, Chen, L, Ridley, A, Cortes, A, Knight, JC, Bowness, P, Cohen, CJ, Wordsworth, BP
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	BMJ Publishing Group 2016

Benzer Materyaller

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
Yazar:: Roberts, A, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
Yazar:: Roberts, AR, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
Yazar:: Roberts, A, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
Yazar:: Cohen, C, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Perspectives on the genetic associations of ankylosing spondylitis
Yazar:: Wordsworth, BP, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
Yazar:: Vecellio, M, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
Yazar:: Cohen, CJ, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

Increased IL-23 Receptor Expression Is Observed On KIR3DL2+CD4+T Cells In Ankylosing Spondylitis and Correlates With IL-23R Polymorphisms
Yazar:: Ridley, A, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Increased IL-23 receptor expression is observed on KIR3DL2+CD4+T cells in Ankylosing Spondylitis and correlates with IL-23R polymorphisms
Yazar:: Ridley, A, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

A meta-analysis of IL23R associations with ankylosing spondylitis
Yazar:: Karaderi, T, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
Yazar:: Vecellio, M, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism
Yazar:: Vecellio, M, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
Yazar:: Appleton, LH, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
Yazar:: Vecellio, M, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis
Yazar:: Cohen, CJ, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Biological and genetic evaluation of IL-23/IL-17 pathway in ankylosing spondylitis patients
Yazar:: Hulya Deveci, ve diğerleri
Baskı/Yayın Bilgisi: (2020-01-01)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
Yazar:: Vecellio, M, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Association of IL23R and ARTS1 genes with susceptibility to ankylosing spondylitis among a Mediterranean/Portuguese population
Yazar:: Harvey, D, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Il-23r is a major determinant of ankylosing spondylitis risk - The tasc study
Yazar:: Reveille, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Replication of association of IL1 gene complex members with ankylosing spondylitis in Taiwanese Chinese.
Yazar:: Chou, C, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Replication of association of IL-1 gene cluster members with ankylosing spondylitis (AS) in Taiwanese Chinese.
Yazar:: Timms, A, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Fine-mapping of the IL-1 gene cluster pinpoints genetic associations with ankylosing spondylitis.
Yazar:: Sims, A, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Genotypic effects of ankylosing spondylitis associated il7r polymorphisms are mediated through monocytes in inflammation
Yazar:: Al-Mossawi, H, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
Yazar:: Vecellio, ML, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Association of <i>ERAP1</i> and <i>IL23R</i> gene polymorphisms with ankylosing spondylitis
Yazar:: U. A. Yakubova, ve diğerleri
Baskı/Yayın Bilgisi: (2020-09-01)

ANTXR2 IS ASSOCIATED WITH ANKYLOSING SPONDYLITIS
Yazar:: Karaderi, T, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

The immunology of Ankylosing Spondylitis
Yazar:: Bowness, P
Baskı/Yayın Bilgisi: (2011)

Interleukin 23 receptor and susceptibility to ankylosing spondylitis
Yazar:: Pointon, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations
Yazar:: Roberts, A, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Determination of IL-23 receptor expression and gene polymorphism (rs1884444) in Iranian patients with ankylosing spondylitis
Yazar:: Atiyeh Mellati, ve diğerleri
Baskı/Yayın Bilgisi: (2024-04-01)

Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
Yazar:: Hanna Przepiera-Będzak, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

ANKYLOSING SPONDYLITIS IS STRONGLY ASSOCIATED WITH VARIANTS IN THE CMG2 GENE
Yazar:: Karaderi, T, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

THE IL1 GENE CLUSTER IS A MAJOR LOCUS DETERMINING SUSCEPTIBILITY TO ANKYLOSING SPONDYLITIS
Yazar:: Timms, A, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

The IL1 gene cluster is a major locus determining susceptibility to Ankylosing spondylitis.
Yazar:: Timms, A, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
Yazar:: Bowness, P
Baskı/Yayın Bilgisi: (2012)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Yazar:: Holden, W, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

CHARACTERIZING TYPE 17 IMMUNE RESPONSES IN ANKYLOSING SPONDYLITIS
Yazar:: Al-Mossawi, H, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

The association of a common functional polymorphism in the tumour necrosis factor receptor 1 gene (TNFRSF1A) and disease severity in ankylosing spondylitis
Yazar:: Watts, L, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Genetics of ankylosing spondylitis.
Yazar:: Brown, M, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
Yazar:: Wordsworth, B, ve diğerleri
Baskı/Yayın Bilgisi: (2017)